Discovery of Novel Bacteriophage with the Capacity to Modulate Gut Bacteria

该项目旨在通过实验验证肠道微生物组中有史以来最大的细菌病毒(噬菌体)收集。该项目希望通过使用湿法实验室和生物信息学基因组分析的创新方法，在噬菌体生物学和基因组学领域产生新的知识。该项目的预期结果包括利用生物信息学发现新的噬菌体，湿法实验室验证其活性，并表征其贡献新细菌宿主新陈代谢的潜力。这应该会带来好处，比如促进我们对噬菌体的理解，改进生物信息学软件，以及有特色的具有商业价值的细菌菌株和噬菌体的集合。

This project aims to experimentally validate the largest ever collection of bacterial viruses (bacteriophages) within the gut microbiome. This project expects to generate new knowledge in the area of bacteriophage biology and genomics by using the innovative approaches of wet-lab and bioinformatic genome analyses. Expect outcomes of this project include the discovery of novel phages using bioinformatics, wet-lab validation of their activity and characterisation of their potential to contribute new bacterial host metabolism. This should provide benefits, such as advancement to our understanding of bacteriophages, improved bioinformatic software, and a characterised collection of commercially valuable bacterial strains and phages.