Unlocking biocatalytic hydrogenation for bulk chemical manufacture

** hydrogen **是牛津大学化学系于2021年分拆出来的项目。我们的愿景：氢技术为更清洁、更安全、更快速、更便宜的化学品生产提供了潜力。我们希望我们的技术在英国化工行业发挥作用，实现雄心勃勃的净零排放目标（到2050年），并越来越多地采用工业生物催化和连续流工艺等技术。目前，我们正在解决制药和特种化学品（如香精和香料）生产方面的挑战。然而，这些高价值的化学品通常只在小范围内需要。**重点：**在这个项目中，我们通过在散装化学品生产中使用我们的技术来应对挑战-即支撑所有制造的化学品：制造化学产品和解决方案的企业是不可或缺的\[...to ca\] 96% of all manufactured goods'_ (source: CIA). These low-value chemicals are required at a large scale, therefore the potential benefits of improving sustainability are maximised.To enter the low-value, high-volume bulk chemical market, we first need to lower the cost-of-production of our technology -- a biocatalyst system that allows companies to replace toxic heavy metals and decrease waste produced by typical bio-processes - to provide a resource and energy efficient 'slot-in' alternative to state-of-the-art processes.Next, we select a demonstrator process (case-study), the manufacture of a bulk chemical that is used for the production of drugs, polymers and consumer products. At present there is no UK-based manufacture of this chemical, but we hope to develop a process than enables cost-competitive manufacture in the UK.

**HydRegen** is a 2021 spin-out from the University of Oxford's Department of Chemistry.**Our vision:** The HydRegen technologies offer the potential for cleaner, safer, faster and cheaper chemical manufacture.We expect our technologies to play a part in the UK chemicals sector meeting ambitious Net Zero emissions targets (by 2050) and increasing adoption of enabling technologies such as Industrial Biocatalysis and continuous flow process.Currently we are addressing challenges in the manufacture of pharmaceuticals and speciality chemicals (e.g. flavours and fragrances). However, these high-value chemicals are typically required only at a small scale.**Focus:** In this project, we tackle challenges with using our technologies in the manufacture of bulk chemicals -- that is, the chemicals that underpin all manufacturing: '_businesses who make chemical products and solutions are integral \[...to ca\]96% of all manufactured goods'_ (source: CIA). These low-value chemicals are required at a large scale, therefore the potential benefits of improving sustainability are maximised.To enter the low-value, high-volume bulk chemical market, we first need to lower the cost-of-production of our technology -- a biocatalyst system that allows companies to replace toxic heavy metals and decrease waste produced by typical bio-processes - to provide a resource and energy efficient 'slot-in' alternative to state-of-the-art processes.Next, we select a demonstrator process (case-study), the manufacture of a bulk chemical that is used for the production of drugs, polymers and consumer products. At present there is no UK-based manufacture of this chemical, but we hope to develop a process than enables cost-competitive manufacture in the UK.