Multiscale models in immuno-epidemiology

病原体(例如病毒或细菌)在种群中的传播是一个多尺度现象，受到种群和宿主内部因素的影响。在人口规模上，传播受感染宿主的传染性程度的影响。感染性反过来又取决于病原体在宿主内复制和免疫/药物控制机制之间的平衡。该项目旨在开发同时对这两个尺度进行建模的新的数学框架。这将为严格研究复杂的生物相互作用--例如抗药性的出现和抗击--提供一个平台，这些相互作用塑造了社会控制人类、动物和植物系统传染病的能力。

The spread of a pathogen (for example, a virus or bacteria) through a population is a multi-scale phenomena, influenced by factors acting at both the population and within-host scales. At the population scale, transmission is influenced by how infectious an infected host is. Infectiousness in turn depends on the balance between pathogen replication within the host and immune/drug control mechanisms. This project aims to develop new mathematical frameworks for simultaneously modelling these two scales. This will provide a platform for the rigorous study of complex biological interactions - such as the emergence and combat of drug-resistance - that shape society's ability to control infectious diseases in human, animal and plant systems.