Third Coast Center For AIDS Research

项目摘要 第三海岸CFAR：总体 第三海岸艾滋病研究中心（TC CFAR）的广泛、长期使命是利用我们的 跨学科合作，推动整个翻译领域的变革性进展 从发现到实施有效的干预措施--并终结艾滋病毒。许多当地资源， 西北大学（UC），芝加哥大学（UC）和社区合作伙伴已经， 将继续承担这一使命。资助研究基地（FRB） 从2014财年到2018财年，项目数量增加了47%，项目变得更加跨学科。灵活和 机会主义战略规划（由行政核心AC）和种子资金的强劲增长 和指导计划（由发展核心，DC）导致了这些成功，并选择 具体的，高度优先的艾滋病毒研究课题作为重点的第二个任期。机构支持有所增加。 总体科学目标也是根据3个科学核心中的每一个都有一个用户来选择的 基础和专家资源与每个目标的优势。这些核心中的每一个也都致力于扩展 他们的资源和专业知识，研究人员以外的自己的领域，从而帮助建立 合作。以下总体目标建立在我们坚实的基础上，并将指导每一项科学研究。 核心，与AC和DC合作，协同推进终结艾滋病毒所需的科学。 总体目标1：继续并扩大合作研究，以减缓并最终停止 通过改进艾滋病毒预防和护理的连续性，预防艾滋病毒流行。 总体目标2：增进对加速衰老相关疾病（非艾滋病）的了解 合并症），尽管抑制了HIV病毒血症。 总体目标3：加快发现并增强变革性科学创新的发展能力 这将改善对艾滋病毒感染者的艾滋病毒预防和治疗。

PROJECT SUMMARY THIRD COAST CFAR: OVERALL The broad, long-term mission of the Third Coast Center for AIDS Research (TC CFAR) is to use our trans-disciplinary collaborations to power transformational advances across the translational spectrum from discovery to implementation of effective interventions - and end HIV. Many local resources at Northwestern University (UC), the University of Chicago (UC), and community partners have been, and will continue to be, brought to bear on this mission. The allowable Funded Research Base (FRB) increased by 47%, and projects became more trans-disciplinary, from FY14 to FY18. Nimble and opportunistic strategic planning (by the Administrative Core, AC) and robust growth in seed funding and mentoring programs (by the Developmental Core, DC) led to those successes, and to choosing specific, high-priority HIV research topics as foci for a second term. Institutional support has increased. The Overall scientific aims were also chosen based on each of the 3 scientific Cores having a user base and expert resources with strengths on each aim. Each of these Cores has also worked to extend their resources and expertise to researchers outside their own domains, and thereby helped build collaborations. The following Overall aims build on our solid foundation, and will direct each scientific Core, in concert with the AC and the DC, to synergistically advance the science needed to end HIV. Overall Aim 1: To continue and expand collaborative research that will slow, and eventually stop, the HIV epidemic by improving continuums of HIV prevention and care. Overall Aim 2: To advance understanding of accelerated aging-related illnesses (non-AIDS comorbidities) that occur despite suppression of HIV viremia. Overall Aim 3: To speed discovery and empower development of transformative scientific innovations that will improve HIV prevention and treatment for persons living with HIV.