Administrative Supplement to The When to Worry about Language Study (W2W-L)

项目摘要-原始提交 初级语言障碍（PLI）在生命早期开始，影响6-8%的儿童。虽然语言 干预是最有效的越早交付，规范的变化，在语言习得 幼儿期（此处为24-36个月）妨碍在晚学龄前年龄之前准确识别PLI。的 这项研究提出了一个新的，有理论基础的神经发育框架， 建立一个敏感和特异的模型，以尽早识别PLI。我们的发展- 敏感的，翻译的方法引入了多个创新，包括：（1）表征 幼儿语言的发展模式始于24个月。使用现有技术的方法， 在一个大的社区样本中;（2）将EEG/ERP语言神经生物标志物纳入PLI风险 评估;（3）使用一种新的范式来评估行为和神经的保护作用 父子语言事务中的同步;以及（4）考虑到易怒，一个鲁棒的 早期心理健康风险的发展标记，以加强对语言迟缓幼儿的识别 持续性风险最高。对于拟议的何时担心语言学习（W2 W-L），我们 利用我们对350名婴儿（50%易激惹和50%非易激惹）的资助研究（R 01 MH 107652，Wakschlag， PI），并通过招募200名晚说话幼儿的子样本来丰富它。这将产生一个大的和多样化的 550名24个月大的婴儿样本。我们的关键预测因素将是幼儿出现的语言模式（24-36个月）， 他们的神经生物标志物和交易语言环境中的同步性。我们的核心成果是 学龄前的初级语言障碍（PLI）状态（54个月，当PLI可以被可靠地评估时）， 通过临床表达和接受语言能力的金标准进行评估。具体目标：目标1a。 评估PLI预测的准确性，基于语言的多成分测量，包括密集度 对幼儿在较大年龄时关键语言功能的发育前体的纵向评估，神经 生物标志物。我们将通过定量脑电图评估亲子互动过程中的神经和语言处理 和ERP语音以及在眼动跟踪任务和1b.评估创建一个 可应用于临床实践的PLI早期识别算法，使用交叉验证和 机器学习目的2：检验亲子二元同步缓冲PLI风险的假设。 同时，我们结合联合收割机的行为和新颖的社会脑电图措施，亲子同步性，在自然 互动和定制设计的单词学习任务，以直接测试观察（行为）和神经 (EEG)双元同步影响单词学习。目的3：测试是否考虑幼儿易怒 增强PLI预测。总之，PLI对各种个人-社会和 学术成果。确定PLI风险最高的儿童对于减轻公共卫生负担至关重要 （c）为儿童、家庭和支持他们的系统提供更多的参与计划，并加强有针对性的资源分配。

PROJECT SUMMARY – Original Submission Primary language impairment (PLI) begins early in life and affects 6-8% of children. Although language intervention is maximally effective the earlier it is delivered, normative variation in language acquisition across toddlerhood (here 24-36 months) impedes accurate identification of PLI prior to late preschool age. The proposed study introduces a novel, theoretically- grounded, neurodevelopmental framework designed to generate a sensitive and specific model to identify PLI as early as possible. Our developmentally- sensitive, translational approach introduces multiple innovations including: (1) characterizing the developmental patterning of toddler emergent language beginning at 24 mos. using state-of-the-art methods, within a large community sample; (2) incorporating EEG/ERP neural biomarkers of language into PLI risk assessment; (3) using a novel paradigm to assess the protective effects of both behavioral and neural synchronization within parent-child language transactions; and (4) consideration of irritability, a robust developmental marker of early mental health risk, to enhance identification of those language delayed toddlers at highest risk for persistence. For the proposed When to Worry about Language Study (W2W-L), we capitalize on our funded study of 350 infants (50% irritable and 50% non-irritable) (R01MH107652, Wakschlag, PI) and enrich it via recruitment of a sub-sample of 200 late talking toddlers. This will yield a large and diverse sample of 550 24-month-olds. Our key predictors will be toddler emergent language patterns (24-36 months), their neural biomarkers and synchrony within the transactional language environment. Our central outcome is primary language impairment (PLI) status at preschool age (54 mos., when PLI can be reliably evaluated), assessed via clinical gold standard expressive and receptive language abilities. SPECIFIC AIMS: AIM 1a. Evaluate accuracy of PLI prediction based on multi-component measures of language including intensive longitudinal assessments of toddler developmental precursors of key language functions at older ages, neural biomarkers. We will assess neural and linguistic processing via quantitative EEG during parent-child interaction and ERPs to speech sounds as well as during eye tracking tasks and 1b. Evaluate feasibility of creating an algorithm for early identification of PLI that can be applied in clinical practice, using cross-validation and machine learning. AIM 2: Test the hypothesis that parent-child dyadic synchrony buffers PLI risk For the first time, we combine behavioral and novel social EEG measures of parent-child synchrony during natural interaction and a custom-designed word learning task to directly test how observed (behavioral) and neural (EEG) dyadic synchrony impact word learning. AIM 3: Test whether consideration of toddler irritability enhances PLI prediction. In sum, PLI confers sustained negative effects on a variety of personal-social and academic outcomes. Pinpointing children at highest risk for PLI is critical for reducing the public health burden of PLI for children, families, and the systems supporting them, and enhancing targeted allocation of resources.