ICH Recovery Grant

项目摘要/摘要 在美国，中风是第三大致死原因，也是成人致残的首要原因。更多 成年人每年受中风的影响比阿尔茨海默病、多发性硬化症、肌萎缩侧索硬化症要多 或者帕金森氏症。出血性中风是中风最严重的亚型。估计有40- 50%的出血性中风患者将死亡，80%以上的幸存者在出血后仍致残 卒中。然而，绝大多数对中风后预后的分析主要集中在粗略测量上。 功能结果。 此外，出血性卒中与缺血性卒中不同，在缺血性卒中中，失血会导致受累区域。 在扫描时容易被看到。但是对于出血性中风，不仅我们可以直接看到的区域，而且 附近被大块出血压缩或拉伸的区域可能会受伤。 我们建议对500例深部和叶部脑出血患者进行随访，以进行运动和运动功能的系列评估 认知功能和高级神经成像，以确定康复、进行性认知或 功能障碍。我们的建议的好处是增加了一项预期的非物质文化遗产研究，该研究将 识别和招募病例，评估存活率和严重性偏差的程度和影响的能力，基线 神经成像，包括基线MRI，生物样本，包括载脂蛋白E等位基因分型 和统一的表型定义以及在恢复/结果分析、高级神经成像方面的专业知识 过程和流行病学研究。

Project Summary/Abstract Stroke is the third leading cause of death and the leading cause of adult disability in the United States. More adults are affected by stroke each year than Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis or Parkinson’s disease. Hemorrhagic strokes represent the most severe subtypes of stroke. An estimated 40- 50% of hemorrhagic stroke victims will die and more than 80% of survivors remain disabled after hemorrhagic stroke. Yet the vast majority of analyses on outcome after stroke have focused principally on gross measures of functional outcome. Furthermore, hemorrhagic stroke differs from ischemic stroke where a loss of blood causes the area affected to be readily visible on scanning. But with hemorrhagic stroke, not only the area that we can directly see, but nearby tracts that have been compressed or stretched by the mass of the hemorrhage can be injured. We propose to follow-up on 500 cases of deep and lobar ICH to perform serial evaluations of motor and cognitive function and advanced neuroimaging to determine predictors of recovery, progressive cognitive or functional impairment. Our proposal has the advantages of adding onto a prospective ICH study which will identify and recruit cases, ability to evaluate for the degree and impact of survival and severity biases, baseline neuroimaging which includes baseline MRI, biologic samples including genotyping for apolipoprotein E alleles and uniform phenotype definitions as well as expertise in recovery/outcome analyses, advanced neuroimaging processes and epidemiologic study.