Cerebrovascular Fellowship Training Program

这项高度集中、竞争激烈的研究培训补助金(T-32)续签申请旨在将医生培养为脑血管疾病和神经危重护理领域的独立临床科学家。我们目前的培训计划包括在NIH资助的、以T-2为重点的翻译研究的广泛范围内的临床研究和试验方面的广泛实践经验。我们的计划包括密切指导，在计划的第一年内选择具体的研究项目，明确的课程工作，以及在急性中风和神经危重护理患者的评估和治疗方面的独特培训。我们的博士后培训计划已经培训了22年的神经科医生和16年的正式急诊医生，目标是培养脑血管疾病和神经危重护理领域的学术领袖和临床研究人员。我们计划的最后15年包括了这款T32的资金。自T32启动以来，我们开发了一种非常强大的神经危重护理培训路径，我们已将其作为T32培训计划的一部分。这种创新和多学科的培训模式得到了NIH路线图和NIH资助的临床和转化科学与培训中心(CCTST)的倡导。我们的培训计划由广泛的合作者和导师网络组成，这使得我们的毕业生在学术上提高了效率。培训的教师具有以下专业知识：急性中风治疗和临床试验方法/管理、基因组学、出血性中风、中风和血管生理学的动物模型和体外模型、创伤性脑损伤、神经危重护理方法、神经流行病学、生物统计学、神经介入治疗(血管内和外科)、神经成像、神经康复、神经声学、神经技术开发、结果研究、中风预防、研究的伦理设计、HIPAA遵从性和数据库管理。新的这份意见书是对所追求的临床/转化性中风研究类型的额外关注；我们现在为那些打算进行设计和实施临床试验的人提供了途径，并为那些对流行病学/结果/遗传学途径更感兴趣的人提供了单独的途径。在T32期间之前和期间在我们项目中接受培训的人员，从学术任命、出版物和随后的拨款来衡量，到目前为止都很有成效。这一相对罕见的T32计划是为从事临床研究的博士后内科科学家设计的，这对今天存在的标准中风临床培训计划具有重要意义，也是迫切需要的价值。潜在的受训者必须完成神经学或急诊医学的住院医师资格，并必须证明致力于脑血管疾病和/或神经危重护理的学术生涯；强调招募少数族裔。我们要求继续为每年最多四个博士后职位提供支助(两年的培训支助每年最多两名研究员)。

This highly focused, competitive renewal application for a Research Training Grant (T-32) is designed to develop physicians as independent clinical scientists in the area of cerebrovascular disease and neurocritical care. Our current training program includes extensive hands-on experience in clinical research and trials within a broad array of NIH-funded, T-2-focused, translational research. Our program includes close mentoring with selection of specific research projects within the first year of the program, well-defined course work, and unique training in the evaluation and treatment of patients with acute stroke and neurocritical care. Our post-doctoral training program has been training neurologists for 22 years and emergency physicians formally for 16 years with the goal of producing academic leaders and clinical researchers in the area of cerebrovascular disease and neurocritical care. The last 15 years of our program have included funding by this T32. Since the initiation of the T32, we have developed a very robust neurocritical care training pathway which we have included as part of this T32 training program. This innovative and multi-disciplinary training model has been advocated by the NIH roadmap and by the NIH-funded Centers for Clinical and Translational Science and Training (CCTST). Our training program is comprised of an extensive network of collaborators and mentors that has resulted in academic productivity among our graduates. Training draws on faculty with expertise in acute stroke therapy and clinical trial methodology/management, genomics, hemorrhagic stroke, animal models and in-vitro models of stroke and vascular physiology, traumatic brain injury, methods of neurocritical care, neuroepidemiology, biostatistics, neuro-interventional therapy (endovascular and surgical), neuroimaging, neurorecovery, neurosonology, neurotechnology development, outcome research, stroke prevention, ethical design of research, HIPAA compliance, and data-base management. New this submission is an additional level of focus on the type of clinical/translational stroke research pursued; we now have pathways for those that intend to pursue designing and implementing clinical trials, and a separate track for those interested in more of the epidemiology/outcomes/genetics path. Individuals trained in our program prior to and during the T32 period have been productive thus far as measured by academic appointments, publications, and subsequent grant awards. This relatively rare T32 program designed for post-doctoral physician scientists performing clinical research is significant and desperately needed value added to the standard stroke clinical training programs that exist today. Potential trainees must have completed a residency in neurology or emergency medicine and must demonstrate a commitment to an academic career in cerebrovascular disease and/or neurocritical care; minority recruitment is emphasized. We are requesting continuing support for up to four post-doctoral positions per year (maximum of two fellows per year for two years of training support).