Cerebrovascular Fellowship Training Program

脑血管奖学金培训计划

• 批准号: 10665618
• 负责人: Daniel Woo
• 金额: $ 39.21万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665618
• 关键词: Fellowship; Training Programs; cerebrovascular

This highly focused, competitive renewal application for a Research Training Grant (T-32) is designed to develop physicians as independent clinical scientists in the area of cerebrovascular disease and neurocritical care. Our current training program includes extensive hands-on experience in clinical research and trials within a broad array of NIH-funded, T-2-focused, translational research. Our program includes close mentoring with selection of specific research projects within the first year of the program, well-defined course work, and unique training in the evaluation and treatment of patients with acute stroke and neurocritical care. Our post-doctoral training program has been training neurologists for 22 years and emergency physicians formally for 16 years with the goal of producing academic leaders and clinical researchers in the area of cerebrovascular disease and neurocritical care. The last 15 years of our program have included funding by this T32. Since the initiation of the T32, we have developed a very robust neurocritical care training pathway which we have included as part of this T32 training program. This innovative and multi-disciplinary training model has been advocated by the NIH roadmap and by the NIH-funded Centers for Clinical and Translational Science and Training (CCTST). Our training program is comprised of an extensive network of collaborators and mentors that has resulted in academic productivity among our graduates. Training draws on faculty with expertise in acute stroke therapy and clinical trial methodology/management, genomics, hemorrhagic stroke, animal models and in-vitro models of stroke and vascular physiology, traumatic brain injury, methods of neurocritical care, neuroepidemiology, biostatistics, neuro-interventional therapy (endovascular and surgical), neuroimaging, neurorecovery, neurosonology, neurotechnology development, outcome research, stroke prevention, ethical design of research, HIPAA compliance, and data-base management. New this submission is an additional level of focus on the type of clinical/translational stroke research pursued; we now have pathways for those that intend to pursue designing and implementing clinical trials, and a separate track for those interested in more of the epidemiology/outcomes/genetics path. Individuals trained in our program prior to and during the T32 period have been productive thus far as measured by academic appointments, publications, and subsequent grant awards. This relatively rare T32 program designed for post-doctoral physician scientists performing clinical research is significant and desperately needed value added to the standard stroke clinical training programs that exist today. Potential trainees must have completed a residency in neurology or emergency medicine and must demonstrate a commitment to an academic career in cerebrovascular disease and/or neurocritical care; minority recruitment is emphasized. We are requesting continuing support for up to four post-doctoral positions per year (maximum of two fellows per year for two years of training support).

这项研究培训补助金（T-32）的高度集中，竞争性更新申请旨在将医生培养为脑血管疾病和神经危重症护理领域的独立临床科学家。我们目前的培训计划包括广泛的临床研究和试验实践经验，在美国国立卫生研究院资助，t -2为重点，转化研究。我们的项目包括在第一年选择特定研究项目的密切指导，明确的课程工作，以及对急性中风患者和神经危重症患者的评估和治疗的独特培训。我们的博士后培养计划已经培养了22年的神经科医生和16年的急诊医生，目标是在脑血管疾病和神经危重症护理领域培养学术领袖和临床研究人员。过去15年我们的项目包括T32的资助。自从T32启动以来，我们已经开发了一个非常强大的神经危重症护理培训途径，我们已经将其作为T32培训计划的一部分。NIH路线图和NIH资助的临床和转化科学与培训中心（CCTST）一直倡导这种创新的多学科培训模式。我们的培训计划由广泛的合作者和导师网络组成，这导致了我们毕业生的学术生产力。培训利用在急性中风治疗和临床试验方法/管理、基因组学、出血性中风、中风和血管生理学的动物模型和体外模型、创伤性脑损伤、神经危重症护理方法、神经流行病学、生物统计学、神经介入治疗（血管内和外科）、神经影像学、神经恢复、神经超声学、神经技术发展、结果研究、中风预防、研究的伦理设计、HIPAA遵从性和数据库管理。新提交的是对临床/转化脑卒中研究类型的额外关注；我们现在为那些打算设计和实施临床试验的人提供了途径，为那些对流行病学/结果/遗传学更感兴趣的人提供了单独的途径。到目前为止，通过学术任命、出版物和随后的拨款奖励来衡量，在T32之前和期间接受我们项目培训的个人都是富有成效的。这个相对罕见的T32项目是为从事临床研究的博士后医师科学家设计的，对目前存在的标准中风临床培训项目来说，这是一个重要的、迫切需要的附加价值。潜在的受训者必须完成神经病学或急诊医学的住院医师培训，并且必须证明对脑血管疾病和/或神经危重症护理的学术生涯的承诺；强调少数民族的招聘。我们要求继续支持每年最多四个博士后职位（每年最多两个研究员，为期两年的培训支持）。

项目成果

The Effect of Antidepressants on Depression After Traumatic Brain Injury: A Meta-analysis.

• DOI: 10.1097/htr.0000000000000439
• 发表时间: 2019
• 期刊: The Journal of head trauma rehabilitation
• 作者: Kreitzer N;Ancona R;McCullumsmith C;Kurowski BG;Foreman B;Ngwenya LB;Adeoye O
• 通讯作者: Adeoye O

The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial.

• DOI: 10.1161/strokeaha.108.517656
• 发表时间: 2008-12
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Pancioli AM;Broderick J;Brott T;Tomsick T;Khoury J;Bean J;del Zoppo G;Kleindorfer D;Woo D;Khatri P;Castaldo J;Frey J;Gebel J Jr;Kasner S;Kidwell C;Kwiatkowski T;Libman R;Mackenzie R;Scott P;Starkman S;Thurman RJ;CLEAR Trial Investigators
• 通讯作者: CLEAR Trial Investigators

Analysis of tissue plasminogen activator eligibility by sex in the Greater Cincinnati/Northern Kentucky Stroke Study.

• DOI: 10.1161/strokeaha.114.006737
• 发表时间: 2015-03
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Madsen TE;Khoury JC;Alwell KA;Moomaw CJ;Kissela BM;De Los Rios La Rosa F;Woo D;Adeoye O;Flaherty ML;Khatri P;Ferioli S;Kleindorfer D
• 通讯作者: Kleindorfer D

The Experience of Caregivers Following a Moderate to Severe Traumatic Brain Injury Requiring ICU Admission.

• DOI: 10.1097/htr.0000000000000525
• 发表时间: 2020
• 期刊: JOURNAL OF HEAD TRAUMA REHABILITATION
• 影响因子: 2.4
• 作者: Kreitzer, Natalie;Bakas, Tamilyn;Kurowski, Brad;Lindsell, Christopher J.;Ferioli, Simona;Foreman, Brandon;Ngwenya, Laura B.;Thomas, Stephanie;Keegan, Sara;Adeoye, Opeolu
• 通讯作者: Adeoye, Opeolu

Ethnic and Racial Variation in Intracerebral Hemorrhage Risk Factors and Risk Factor Burden.

• DOI: 10.1001/jamanetworkopen.2021.21921
• 发表时间: 2021-08-02
• 期刊: JAMA network open
• 影响因子: 13.8
• 作者: Kittner SJ;Sekar P;Comeau ME;Anderson CD;Parikh GY;Tavarez T;Flaherty ML;Testai FD;Frankel MR;James ML;Sung G;Elkind MSV;Worrall BB;Kidwell CS;Gonzales NR;Koch S;Hall CE;Birnbaum L;Mayson D;Coull B;Malkoff MD;Sheth KN;McCauley JL;Osborne J;Morgan M;Gilkerson LA;Behymer TP;Demel SL;Moomaw CJ;Rosand J;Langefeld CD;Woo D
• 通讯作者: Woo D