Nutrition-specific interventions to improve long-term maternal-child health outcomes

项目总结 实现可持续发展目标的2030年孕产妇和儿童发病率和死亡率目标将 需要对最脆弱的人群进行持续和有效的公共卫生干预。总的目标是 这项申请的目的是继续参加与全球环境基金的使命有关的所有协作活动 网络(GN)，旨在通过协作、大型 规模大、影响大、多地点通用研究协议。我们研究单位(RU)的主要目标是， 代表着科罗拉多大学和危地马拉之间的合作伙伴关系，是开发和 实施针对营养的干预措施，以减轻产前和产后营养不良的影响，从而 改善母婴健康状况。这一目标将通过以下具体目标实现： 1)继续作为GN成员保持良好的研究记录和生产力；2)继续培养 与我们在危地马拉和其他GN站点的同事逐步加强研究伙伴关系；以及3) 继续制定针对营养的干预措施，作为全球卫生组织的共同方案。在过去5年的周期中， RU已经建立了强大的研究记录，这一点从领导两个主要的营养特定共同 方案，包括先入为主的孕产妇营养干预试验；加强了研究 危地马拉的能力；参与制定和实施所有由全球网络发起的共同 对每项研究贡献较高百分比的群组/参与者数量的方案； 报告GN支持的试验结果的出版物的生产率(与GN合著者共60份)；以及 成功地获得重大外部资金，以支持共同议定书的执行。主修 该研究组对GN的贡献包括共同主持议定书审查小组委员会和监督 正在进行的孕产妇和新生儿健康登记委员会。成功的指导和能力建设 NICHD邀请资深外国调查员担任多个国家的现场负责人，这证明了RU 孕期寨卡病毒暴露的观察性研究。我们持续参与的积极影响 在全球网络中，将通过确定营养--加强全球网络的多学科能力-- 改善母婴健康的具体干预措施。这种合作研究将加速 制定循证政策，以减轻全球营养不良和其他不利健康的负担 结果。

PROJECT SUMMARY Meeting the Sustainable Development Goals' 2030 targets for maternal and child morbidity and mortality will require sustained and effective public health interventions for the most vulnerable populations. The broad goal of this application is to continue to participate in all collaborative activities relevant to the mission of the Global Network (GN), which aims to develop and test potential sustainable interventions through collaborative, large- scale, high-impact, multi-site common research protocols. The primary objective of our research unit (RU), which represents a partnership between the University of Colorado and Guatemala, is to develop and implement nutrition-specific interventions to mitigate the effects of pre- and post-natal malnutrition and thereby to improve maternal and infant health outcomes. This objective will be met through the following specific aims: 1) continue to maintain a strong research record and productivity as GN members; 2) continue to foster a progressively stronger research partnership with our colleagues in Guatemala and other GN sites; and 3) continue to develop nutrition-specific interventions as GN common protocols. During the past 5-yr cycle, this RU has built a strong research record, as evidenced by having led two major nutrition-specific common protocols, including the preconception maternal nutrition intervention trial; having strengthened the research capacity in Guatemala; participation in the development and implementation of all GN-initiated common protocols with contribution of a high percentage of cluster/participant numbers to each study; strong productivity in publications (total of 60 with GN co-authors) that report findings of GN supported trials; and having successfully obtained major external funding to support common protocol implementation. Major contributions to the GN by this RU include co-chairing the Protocol Review Sub-committee and the oversight committee for the ongoing Maternal Newborn Health Registry. Successful mentoring and capacity building for the RU is evidenced from invitation by NICHD for the Sr. Foreign Investigator to be site lead for a multi-country observational study of Zika virus exposure during pregnancy. The positive impact of our continued participation in the GN will be to strengthen the multi-disciplinary capacity of the Global Network by identifying nutrition- specific interventions to improve maternal and infant health. Such collaborative research will accelerate the development of evidence-based policies to reduce the global burden of malnutrition and other adverse health outcomes.