Vanderbilt O'Brien Kidney Center

范德比尔特奥布莱恩肾脏中心（VOKC）的使命是推进研究 肾脏相关研究的机会，并促进 基础科学家和临床研究人员，以促进有效的预防和 急性和慢性肾脏疾病及其并发症的治疗。完成其 使命，范德比尔特奥布莱恩肾脏中心支持生物医学研究核心， 试点和可行性赠款以及一个强有力的教育充实方案。有 三个生物医学研究中心，为研究人员提供服务， 肾损伤的临床前模型：表型和病理生理学核心， 组织学和分子病理学核心和细胞和基因组工程核心， 一个强大的临床和翻译核心，为参与翻译和 流行病学研究。这些核心支持肾脏研究，由92 范德比尔特的调查员此外，我们开发VOKC的目标是让它服务于 作为一种国家和国际资源，而且，正如在说明中所指出的， 生物医学研究基地，美国和国外机构的研究人员已经 利用生物医学核心的资源;此外，我们还为一个 一些制药公司。在上一个供资期间，该中心 支持的研究为发病机制和治疗提供了新的见解， 糖尿病肾病、高血压、急性肾损伤、肾小球和 肾小管间质纤维化和慢性肾病并发症。

The mission of the Vanderbilt O'Brien Kidney Center (VOKC) is to advance research opportunities for kidney related research and promote effective interactions between basic scientists and clinical researchers in order to advance effective prevention and treatment of acute and chronic kidney disease and their complications. To accomplish its mission, the Vanderbilt O'Brien Kidney Center supports Biomedical Research Cores, Pilot and Feasibility Grants and a robust Educational Enrichment Program. There are three Biomedical Research Cores that provide services to investigators utilizing preclinical models of kidney injury: a Phenotyping and Pathophysiology Core, an Histology and Molecular Pathology Core and a Cell and Genome Engineering Core and a robust Clinical and Translation Core for investigators involved in translational and epidemiologic research. These Cores support kidney research that is conducted by 92 investigators at Vanderbilt. In addition, our goal in developing the VOKC is for it to serve as a national and international resource, and, as indicated in the description of the Biomedical Research Base, investigators at institutions in both the U.S. and abroad have utilized resources of the Biomedical Core; in addition, we have provided services to a number of pharmaceutical companies. During its previous funding period, the Center supported studies that have provided new insights into the pathogenesis and treatment of diabetic nephropathy, hypertension, acute kidney injury, glomerular and tubulointerstitial fibrosis and complications of chronic kidney disease.