Cytoscape: A Modeling Platform for Biomolecular Networks

本申请是根据NOT-HG-20-030提交的。我们将使用数据驱动的网络， Cytoscape生态系统工具和资源支持的分层建模技术， SARS-CoV-2感染，并将使用这些模型提出宿主反应差异的机制， 分析群体遗传学和COVID-19疾病结果数据。这些数据驱动的模型将为 研究人群风险分层和潜在的COVID-19疗法。我们的模型、分析结果和 将通过一个网站和数据储存库向研究界提供这套工具。模特们将在 来自分子和遗传相互作用数据，并将用于分析人口数据， SARS-CoV-2感染、合并症和临床结果目前由英国生物银行收集。的 分析将定期更新，每次发布的数据，保持最新的资源， 研究社区。建模工具和管道将是用户友好的和有据可查的， 研究人员建立替代模型或分析其他人口数据。

This application is being submitted in response to NOT-HG-20-030. We will use data-driven network and hierarchical modeling techniques enabled by Cytoscape ecosystem tools and resources to build models of SARS-CoV-2 infection and will use the models to propose mechanisms of variance in host response based on the analysis of population genetic and COVID-19 disease outcome data. These data-driven models will inform research in population risk stratification and potential COVID-19 therapies. Our models, analysis results, and toolset will be made available to the research community via a website and data repository. The models will be derived from molecular and genetic interaction data and will be used to analyze population data on SARS-CoV-2 infection, comorbidities, and clinical outcomes currently being collected by the UK BioBank. The analysis will be updated periodically with each release of data, maintaining an up-to-date resource for the research community. The modeling tools and pipelines will be user-friendly and well-documented, enabling researchers to build alternative models or to analyze other population data.