Tufts Clinical and Translational Science Institute (N3C Supplement)

项目摘要 塔夫茨临床和转化科学研究所（Tufts CTSI）基于以下信念： 整个临床和转化研究（CTR）的真实参与是 这对实现生物医学科学满足公众需求的承诺至关重要。这 不仅包括从工作台到床边的平移（T1平移），而且至关重要的是， 具有健康影响，转化为有效的临床实践（T2），护理提供和公众 健康（T3）和健康政策（T4）。所有这些方面的进展越来越依赖于 有效利用来自多个领域的科学数据。 COVID-19全球紧急情况既是一个紧迫的挑战，也是一个机遇， NIH强调的重要数据共享目标的进展。作为回应，NCATS和 转化科学奖中心（CTSA）中心，几个HHS机构和其他 合作组织致力于开发下一代临床知识库， 与COVID-19相关的数据，国家COVID队列协作（N3 C），作为一种手段， 加速全球对该疾病的研究并帮助诊断技术的发展， 治疗剂和有效的疫苗。N3 C计划的目标是提高效率， 临床数据分析的可访问性与以下主要信息学目标一致： 塔夫茨CTSI，这是为了减少障碍，整合医疗保健和研究， 提供创新的系统、数据存储库和分析工具， 通过互操作性、标准化和资源共享实现交流和协作。在- 根据共同的目标，在本补编中，我们寻求为N3 C倡议做出贡献， 数据提供商和思想合作伙伴通过以下具体目标：（1）继续发挥 为N3 C的分析平台提供工具和资源的重要角色;以及（2）确保Tufts CTSI的信息学计划有足够的工作人员和技术资源，继续提供 COVID特定患者数据从我们的中心到N3 C存储库。

PROJECT SUMMARY Tufts Clinical and Translational Science Institute (Tufts CTSI) is based on the conviction that authentic involvement of the entire spectrum of clinical and translational research (CTR) is critical to fulfilling the promise of biomedical science for meeting the public's needs. This includes not only from translation from bench to bedside (T1 translation), but also, crucially for having health impact, translation into effective clinical practice (T2), care delivery and public health (T3), and health policy (T4). Advances on all of these fronts is increasingly dependent on making effective use of scientific data from multiple domains. The COVID-19 global emergency presents both an immediate challenge and an opportunity to progress on important data sharing aims emphasized by NIH. In response, NCATS and the Centers for Translational Science Award (CTSA) hubs, several HHS agencies, and other partnering organizations have committed to developing a next-generation repository for clinical data related to COVID-19, the National COVID Cohort Collaborative (N3C), as a means of accelerating global research into the disease and aiding the development of diagnostics, therapeutics, and effective vaccines. The N3C initiative's goal of improving the efficiency and accessibility of analyses with clinical data is consistent with the primary informatics objectives of Tufts CTSI, which am to reduce barriers to the integration of healthcare and research by providing innovative systems, data repositories, and analytical tools, and by enabling greater exchange and collaboration through interoperability, standardization, and resource sharing. In- line with shared objectives, in this supplement we seek to contribute to the N3C initiative as a data provider and thought partner through the following specific aims: (1) continue to play an important role providing tools and resources for N3C's analytics platform; and (2) ensure Tufts CTSI's Informatics Program has sufficient staff and technical resources to continue to provide COVID-specific patient data from our hub to the N3C repository.