National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Core Project

项目摘要 该项目是为响应RFA-AG-21-008而开发的，描述了数据收集和 全国青少年与成人健康纵向研究第六波(第六波)的传播 (Add Health)，当队列成员的年龄为39-48岁(平均44岁)时。Add Health是一项纵向研究 1994-95年间全国有代表性的20,000多名7-12年级青少年的样本 到目前为止，已经被跟踪了五次。25年来，Add Health收集了丰富的 人口、社会、家庭、社会经济、行为、心理社会、认知和健康调查数据来自 参与者及其家长；来自参与者的学校、社区和 居住地域；与参与者有关的行政数据，包括出生和死亡证明；以及 来自参与者的家庭物理和生物数据，包括人体测量、遗传标记、 血液化验和药物治疗。辅助研究增加了更多信息，包括表观遗传学， 基因表达和微生物组数据。因此，Add Health是非常独特的，因为它具有丰富的、多方面的 一大批具有全国代表性的美国人进入的水平和纵向数据阵列 中年。重要的是，这群人在过渡到中年时的整体健康状况是有问题的 跨越多个维度。此外，按种族、族裔、性别、社会经济地位、性别、性别划分的健康差距 在这一群体中，少数族裔地位和城乡居民的范围很广，在某些情况下，还在扩大。因此，有钱人 迫切需要纵向的、多层次的、具有全国代表性的数据来更好地了解生活 美国成年人进入中年后健康轨迹和健康差距的进程决定因素。第六波 Add Health将满足这一关键需求。Add Health第六波的总体目标是收集和传播 最好地理解社会、经济、心理社会、背景和生物学所需的全面数据 健康轨迹的决定因素和这一具有全国代表性的美国人队列中的差异 他们步入中年。该项目围绕五个目标展开：1)通过以下方式重新访谈队列成员 主要是基于Web的和面对面的模式，明确关注确保来自 种族/少数民族和社会经济地位低的参与者；2)丰富关键领域的学习内容， 将阐明中年和晚年的健康轨迹和差异；3)重新访问同意的队列成员 进行家庭健康检查，其中包括静脉采血和其他重要的健康组成部分；4) 对重要的疾病前期和疾病生物标记物的生物样本进行分析；以及5)清洁， 为科学界记录、传播、归档、推广和支持第六波数据。 该项目对老龄化、健康和健康差距的科学研究具有非凡的潜力。 未来几十年，随着Add Health队列年龄增长到中年及以后。成功结转 该项目的最新进展将为成千上万从事这些关键问题的研究人员提供必要的数据。

Project Summary This project, developed in response to RFA-AG-21-008, describes core plans for data collection and dissemination of the sixth wave (Wave VI) of the National Longitudinal Study of Adolescent to Adult Health (Add Health), when cohort members will be 39-48 years of age (mean 44). Add Health is a longitudinal study of a nationally representative sample of over 20,000 adolescents who were in grades 7-12 during the 1994-95 school year and have been followed for five waves to date. Over 25 years, Add Health has collected rich demographic, social, familial, socioeconomic, behavioral, psychosocial, cognitive, and health survey data from participants and their parents; a vast array of contextual data from participants' schools, neighborhoods, and geographies of residence; administrative data linked to participants, including birth and death certificates; and in-home physical and biological data from participants, including anthropometric measures, genetic markers, blood-based assays, and medications. Ancillary studies have added more information, including epigenetic, gene expression, and microbiome data. Thus, Add Health is exceptionally unique because it has a rich, multi- level, longitudinal array of data for a large nationally representative cohort of Americans who are entering midlife. Importantly, the overall health profile of the cohort as they make the transition to midlife is problematic across many dimensions. Moreover, health disparities by race, ethnicity, gender, socioeconomic status, sexual minority status, and rural-urban residence in this cohort are wide and, in some cases, widening. As such, rich longitudinal, multi-level, and nationally representative data are urgently needed to best understand the life course determinants of health trajectories and health disparities of US adults as they enter midlife. Wave VI of Add Health will fill this critical need. The overall goal of Wave VI of Add Health is to collect and disseminate the comprehensive data needed to best understand the social, economic, psychosocial, contextual, and biological determinants of health trajectories and disparities among this nationally representative cohort of Americans as they age into midlife. The project is focused around five aims: 1) Re-interviewing cohort members using predominantly web-based and in-person modes, with explicit attention to securing high response rates from racial/ethnic minority and low socioeconomic status participants; 2) Enriching study content in key domains that will elucidate mid- and later-life health trajectories and disparities; 3) Re-visiting cohort members who consent for an in-home health exam that includes venous blood collection and other important components of health; 4) Assaying biological specimens for important pre-disease and disease biomarkers; and 5) Cleaning, documenting, disseminating, archiving, promoting, and supporting Wave VI data for the scientific community. This project has extraordinary potential to contribute to the science of aging, health, and health disparities for decades to come, as the Add Health cohort ages into the middle adult years and beyond. Successful carryout of this project will supply essential data for thousands of researchers working on these critical issues.