Piloting Y-AMBIENT: A Quality of Life Intervention for Young African American Breast Cancer Survivors in Treatment

项目总结/摘要 Timiya S.诺兰是俄亥俄州州立大学护理学院的助理教授。诺兰医生是 响应PAR-18-336，以获得必要的技能，知识和指导研究经验 作为一名护士科学家的职业生涯，专注于癌症生存率健康差异研究。她的长期目标 是建立一个独立的研究计划，确定生活质量（QOL）的背景因素， 年轻（18-44岁）的乳腺癌幸存者，来自代表性不足的少数群体，并将研究结果转化为 制定、实施和传播/翻译多层次的生活质量干预措施和政策 变化奖励期的短期目标包括发展生物行为和 环境因素对癌症和健康结果（特别是QOL）的影响， 进行纵向干预和观察性试验，先进的定量方法，手稿 写作和granitarian建立在她的年轻人和非洲人各自领域的存在 美国（AA）乳腺癌幸存者。年轻的AA幸存者报告生活质量较差（QOL）， 健康的负面社会决定因素（例如，社会经济地位低、获得护理的机会有限、歧视） 年轻的白色幸存者。然而，没有发表的干预措施，全面解决生活质量（即， 身体、心理、社会和精神健康）。这一建议旨在 评估年轻AA患者有针对性的QOL干预与对照的过程和初步结果 早期（I-II）和晚期（III）乳腺癌治疗中的幸存者。诺兰博士改编了这个Y-环境 利用年轻AA幸存者和医疗保健人员的投入，从现有的循证干预措施中进行干预 提供商我们将进行一项两组、初步随机对照试验，以评估其可行性、可接受性和 Y-AMBIENT（主题教育、书面材料和视频）与 注意力控制（加强日常护理）。我们将招募40名完成小学学业的年轻AA幸存者 乳腺癌治疗（每组n=20，早期和晚期乳腺癌病史的患者代表性相同） 内乳腺癌分期）。我们将通过研究招募和保留来衡量可行性（即，研究 入组和研究联系完成）和方案可接受性（满意度、有用性、使用 通过我们的主题关注和战略表。我们将定性和定量地 每个研究联系人的回应，以（a）确定参与者对其可接受性的看法，（B） 参与议定书的各个方面（参与者负担），以及（c）使用自我管理战略。在 基线，两个月和五个月，我们将检查健康相关的结果（即，生活质量，精神健康，自我- 功效和社会支持）内和组间使用描述性和多效应模型 技术.在获奖期间完成的指导研究将为大型 Y-AMBIENT的有效性试验和未来确定其他可修改的因素，以解决干预措施。

Project Summary/Abstract Timiya S. Nolan is an Assistant Professor in the College of nursing at The Ohio State University. Dr. Nolan is responding to PAR-18-336 to obtain the skills, knowledge and mentored research experience that are essential for a career as a nurse scientist focusing on cancer survivorship health disparities research. Her long-term goal is to build an independent program of research that identifies contextual factors of quality of life (QOL) among young (18-44) breast cancer survivors from underrepresented minority groups and translates findings to the development, implementation, and dissemination/translation of multi-level QOL interventions and policy changes. The short-term goals for the award period include developing expertise in biobehavioral and environmental contributors to cancer and health outcomes (particularly QOL), scientific processes in the conduct of longitudinal intervention and observational trials, advanced quantitative methods, manuscripts writing and grantsmanship toward building a presence in her respective field among young and African American (AA) breast cancer survivors. Young AA survivors report poorer quality of life (QOL), and face more negative social determinants of health (e.g., low socioeconomic status, limited access to care, discrimination) than young White survivors. Yet, there are no published interventions that comprehensively address QOL (i.e., physical, psychological, social and spiritual well-being) in young AA survivors. This proposal is aimed at evaluating processes and preliminary outcomes of a targeted QOL intervention vs. control in young AA survivors in treatment for early (I-II) & late (III) stage breast cancer. Dr. Nolan adapted this Y-AMBIENT intervention from an existing evidence-based intervention using input from young AA survivors and healthcare providers. We will conduct a two-arm, pilot randomized controlled trial to evaluate feasibility, acceptability, and preliminary health-related outcomes of Y-AMBIENT (themed education, written materials, and videos) vs. an attention control (enhanced usual care). We will recruit 40 young AA survivors who have completed primary breast cancer treatment (n=20 per group and equal representation of those with a history of early and late stage breast cancer within). We will measure feasibility via study recruitment and retention (i.e., study enrollment and study contact completion) and protocol acceptability with satisfaction, usefulness, use of strategies via our Topical Concern and Strategy Sheet. We will triangulate qualitative and quantitative responses from each study contact to (a) identify participants’ perceptions of its acceptability, (b) willingness to participate in aspects of the protocol (participant burden), and (c) use of self-management strategies. At baseline, two-, and five-months, we will examine health-related outcomes (i.e., QOL, spiritual well-being, self- efficacy, and social support) within and between groups using descriptive and multiple-effects modeling techniques. Mentored research accomplished during the award period will lay the foundation for a large efficacy trial of Y-AMBIENT and future identification of other modifiable factors to address with interventions.