The NYU Women's Health Study

项目摘要/摘要 纽约大学女性健康研究(NYUWHS)是一项对14,274名健康女性进行的前瞻性队列研究 在1985-1991年间入学。除了生殖因素、病史和生活方式的数据外，这项研究 在注册时收集所有参与者的血清样本。随后还采集了血清样本。 超过一半的女性来做乳腺癌筛查。所有研究参与者都可以获得DNA。这个 纽约大学发起或参与了乳腺癌、子宫内膜癌、卵巢癌、结直肠癌、肺癌、 胰腺、肾脏、肝脏、大脑和非霍奇金淋巴瘤(NHL)。所研究的暴露包括饮食、生殖 激素、饮食标志物、细胞因子和其他生物标志物的循环水平。 这项研究的总体目标是了解癌症的病因，并提供可能导致 预防。此应用程序的目标是维护和加强研究的基础设施 接下来的五年。具体目标是：1)继续确诊癌症病例；2)继续维持 复杂数据库；3)继续维护血液样本(血清、细胞沉淀物、 和肿瘤组织；4)通过维护研究促进协作和数据共享 网站并及时响应请求；5)继续采集主要癌症部位的肿瘤组织(乳腺癌、 结直肠、子宫内膜和肺)，对于乳腺癌，构建用于分类的肿瘤微阵列 分子亚型；6)通过从大约3,400人中收集粪便样本来扩大生物库 7)评估新的潜在癌症生物标记物的长期重复性。截至2016年1月1日，5047 已确定发生的癌症，预计继续跟踪将发现另外1,277例癌症 癌症病例(总数=5989例)。 NYUWHS的具体优势包括：1)长期跟踪：NYUWHS参与者一直被跟踪- 长达27至33年，风险因素随时间的变化对癌症风险的影响因此 接受检查。2)注册时收集的血清和DNA可供所有参与者使用，使 生物信息库是研究遗传变异、生物标记物和癌症风险之间关系的宝贵资源； 3)可用于评估循环标志物的时间可靠性的重复血清样本是 提供给超过一半的参与者；4)而大多数大型癌症流行病学队列开始 注册年龄为50岁，6659名纽约大学参与者(47%)年龄在35岁至49岁之间 登记/献血，为风险因素和生物标志物的研究提供机会 年轻女性。

PROJECT SUMMARY/ABSTRACT The NYU Women’s Health Study (NYUWHS) is a prospective cohort study of 14,274 healthy women who were enrolled in 1985-1991. In addition to data on reproductive factors, medical history and lifestyle, the study collected serum samples from all participants at enrollment. Serum samples were also collected at subsequent breast cancer screening visits from over half the women. DNA is available for all study participants. The NYUWHS has initiated or participated in studies of cancer of the breast, endometrium, ovary, colorectum, lung, pancreas, kidney, liver, brain, and non-Hodgkin lymphoma (NHL). Exposures studied include diet, reproductive factors, and circulating levels of hormones, dietary markers, cytokines, and other biomarkers. The overall goal of the study is to understand the etiology of cancer and provide information that can lead to prevention. The objectives of this application are to maintain and enhance the infrastructure of the study over the next five years. The specific aims are to: 1) Continue cancer case ascertainment; 2) Continue to maintain the complex database; 3) Continue to maintain the biorepository of blood samples (serum, cell precipitates, and clots) and tumor tissues; 4) Facilitate collaborations and data sharing through maintenance of the study website and timely response to requests; 5) Continue tumor tissue collection for major cancer sites (breast, colorectal, endometrial, and lung) and, for breast cancer, construction of tumor microarrays for classification in molecular subtypes; 6) Expand the biorepository by collecting a stool sample from approximately 3,400 women; 7) Assess the long-term reproducibility of new potential cancer biomarkers. As of 1/1/2016, 5,047 incident cancers have been identified and the continued follow-up is expected to identify an additional 1,277 cancer cases (total = 5989). The specific strengths of the NYUWHS include: 1) Long follow-up: NYUWHS participants have been followed- up for 27 to 33 years, and the impact of changes in risk factors over time in relation to cancer risk can therefore be examined. 2) Serum collected at enrollment and DNA are available for all participants, making the biorepository a valuable resource to study associations between genetic variation, biomarkers, and cancer risk; 3) Repeat serum samples, which can be used to assess temporal reliability of circulating markers, are available for over half of the participants; 4) While the majority of large Cancer Epidemiology Cohorts started enrollment at age 50, 6,659 NYUWHS participants (47%) were between the ages of 35 and 49 at enrollment/blood donation, providing opportunities for the study of risk factors and biomarkers measured in younger women.