Predoctoral Training in Pharmacological Sciences

药理学博士前培训 摘要： 这个博士前药理学科学培训计划（PhTP）的总体目标是教育 下一代生物医学研究人员在药物发现和开发的概念， 提供临床视角。学员主要来自4个研究生课程（药理学和 毒理学，生理学，生物医学工程和神经科学）在不同领域的发展专业知识。 这从经典的药理学和药物靶点鉴定与尖端的方法， 生物化学，结构生物学，基因组学分子和细胞生物学，高分辨率成像， 电生理学和行为生理学，药物化学，微流体工程和其他 设备，疾病的动物模型，新的体内整体动物成像和转化治疗， 临床试验PhTP将在核心原则方面提供针对性和学生量身定制的小组培训 为非药理学学员提供药理学课程，并将这些学生与药理学联系在一起 学生在药物发现和开发方面进行更多的跨学科小组学习。第二个目标是 为了使所有学员能够在大量的研究学科中进行交流和合作， 代表。这一目标主要是通过一个高度创新的、以学生为主导的、以项目为导向的课程来实现的。 解决药理学科学，它每年根据学生的主动性进行自我改造， 兴趣通过这种方式，我们的PhTP培养出具有各种背景的专家， 在日益复杂的领域与其他相关学科的专家进行交流和协作 药物开发。加州大学戴维斯分校有一个非常强大的多学科和协作环境 与这个PhTP有关。UCD赠款更多的学士和博士学位在生物科学比任何其他 美国大学，在授予公立大学的校外研究资金中排名第12位 （每年8亿美元）。51名培训教师来自6所学院的22个部门， 合作互动已经存在。培训师提供深入的专业知识，从确定 新的治疗分子靶点和临床药物和干细胞治疗分子的开发 在NIH资助的UCD临床和转化科学中心（CTSC）和NIH指定的癌症 中心用于治疗心血管、神经和免疫疾病和癌症的新药， 我们PhTP的四个重点领域，已经开发出来，并正在由几个学院带到诊所， UCD.非常丰富和协作的整体科学环境在UCD，强大和众多的国家， 先进的核心设施和中心将为学员提供出色的研究机会， 从化学的重点药物化学，成像分子（从单分子到在 体内）、基因组学、分子/系统建模、干细胞、独特的动物模型（国家认可的 小鼠中心、兽医学校和灵长类动物中心）和CTSC。

PREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIENCES ABSTRACT: The overarching goal of this predoctoral Pharmacological Sciences Training Program (PhTP) is to educate next generation of biomedical researchers in the concepts of drug discovery and development and to provide a clinical perspective. Trainees come mainly from 4 graduate programs (Pharmacology & Toxicology, Physiology, Biomedical Engineering and Neuroscience) developing expertise in diverse areas. This reaches from classic pharmacology and drug target identification with cutting edge methods in biochemistry, structural biology, genomics molecular and cell biology, high resolution imaging, electrophysiology and behavioral physiology, to medicinal chemistry, engineering of microfluidic and other devices, animal models of disease, novel in vivo whole animal imaging and translational therapeutics in clinical trials. The PhTP will provide focused and student-tailored small group training in the core principles of pharmacology for non-pharmacology trainees, and enmesh these students together with pharmacology students for more interdisciplinary group learning in the drug discovery and development. A second goal is to enable all trainees to communicate and collaborate across the large array of research disciplines they represent. This goal is mainly realized in a highly innovative student-driven, project-oriented course Problem Solving in Pharmacological Sciences, which reinvents itself every year based on student initiative and interest. In this way our PhTP produces experts with a variety of backgrounds that can effectively communicate and collaborate with experts from other related disciplines in the increasingly complex realm of drug development. UC Davis has an unusually strong multidisciplinary and collaborative environment related to this PhTP. UCD grants more bachelors and doctoral degrees in biological sciences than any other US university and ranks 12th in the country in extramural research funding awarded to public universities ($800 million annually). The 51 training faculty are from 22 departments in 6 colleges, where extensive collaborative interactions already exist. Trainers provide in depth expertise that ranges from identifying novel therapeutic molecular targets and development of therapeutic molecules to clinical drug and stem cell trials at the NIH-funded UCD Clinical and Translational Science Center (CTSC) and NIH-designated Cancer Center. Novel drugs for treatment of cardiovascular, neurological, and immunological diseases and cancer, the four focus areas of our PhTP, have been developed and are being brought to clinic by several faculty at UCD. The very rich and collaborative overall science environment at UCD, powerful and numerous state-of- the-art core facilities and centers will provide trainees with outstanding research opportunities spanning from Chemistry's emphasis on pharmaceutical chemistry, imaging molecules (from single molecule to in vivo), genomics, molecular/system modeling, stem cells, unique animal models (nationally recognized mouse center, Veterinary School and Primate Center) and CTSC.