Cancer Population Sciences (CPS)

项目摘要/摘要：癌症人口科学 癌症人口科学(CPS)计划汇集了40名教职员工，代表着 达特茅斯的盖泽尔医学院(Geisel)、达特茅斯-希区柯克医学中心(DH)和白人 VT退伍军人管理医疗中心(VA)，研究兴趣与这三项相关 CPS计划的中心主题：1)生命周期癌症流行病学，2)转化人口科学，3) 医疗保健提供科学。CPS计划的共同目标是：1)以人口为基础 了解癌症发生和结局的分子、行为和环境基础的研究 2)为改进癌症筛查的政策和实践建立科学基础， 从预防到生存的整个癌症过程中的护理提供质量和健康结果； 以及3)设计和测试干预措施，并在我们的 集水区，全国和更远的地方。目前由同行评审的癌症相关研究直接成本支持 总计870万美元，其中NCI资金占32%(280万美元)，总直接成本为960万美元。十六(16) CPS计划成员目前共有17个CCSG定义的R01等值奖项。使用相同的 NCI定义的癌症相关直接成本2014年，同行评审的癌症相关研究直接成本为78 与2014年相比增长了2%，但每个成员的资金增加了6%(40个成员为216,234美元，而57个成员为204,161美元 成员)。自2015年以来，CPS方案有994份与癌症有关的出版物，31%(311份)在方案内， 9%(93人)为方案间调查人员，75%(743人)为来自其他机构的调查人员。基于926 with Impact 数据显示，20%(181)是高影响力期刊(即影响因子&gt；8)。与2014年相比，方案内 出版物增加，从29%增加到31%，高影响力增加，从16%增加到20%。在此之前 2018年计划重组，我们的两个人口科学计划有计划间的发表率 13%和19%，这与他们在2014年报告的范围(13%-19%)一致。CPS计划负责人已经 明确了针对未来发展的计划级和主题特定计划。其中包括增强的、跨学科的 由多个学科的高级教员指导初级调查人员；发展和支持 主题工作组(例如肥胖、微生物组、乳腺癌、烟草监管和地理空间研究) 建立跨越人口科学学科和其他学科的合作；以及 培训计划。

Project Summary/Abstract: Cancer Population Sciences The Cancer Population Sciences (CPS) Program brings together 40 faculty, representing 12 departments at Dartmouth’s Geisel School of Medicine (Geisel), Dartmouth-Hitchcock Medical Center (DH) and the White River Junction VT Veterans Administration Medical Center (VA), with research interests relevant to the three central CPS Program themes: 1) Life course cancer epidemiology, 2) Translational population science, and 3) Health care delivery science. The shared goals of the CPS Program are to: 1) conduct population-based studies to understand the molecular, behavioral and environmental basis of cancer occurrence and outcomes across the life course; 2) establish a scientific basis for policies and practices that improve cancer screening, quality of care delivery, and health outcomes across the cancer continuum, from prevention to survivorship; and 3) design and test interventions and promote policies that reduce cancer risk and cancer burden in our catchment area, nationally and beyond. Peer-reviewed cancer-related research direct cost support currently totals $8.7M, with NCI funding representing 32% ($2.8M) and total direct costs summing to $9.6M. Sixteen (16) CPS Program Members currently have a total of 17 CCSG-defined R01-equivalent awards. Using the same NCI definition of cancer-related direct costs in 2014, peer-reviewed cancer-related research direct costs are 78 % compared to 2014, but per Member funding is up 6% ($216,234 for 40 Members vs. 204,161 for 57 Members). Since 2015, the CPS Program has 994 cancer-related publications, 31% (311) intra-programmatic, 9% (93) inter-programmatic, and 75% (743) with investigators from other institutions. Based on 926 with impact data, 20% (181) were high impact journals (i.e., impact factor >8). Compared to 2014, intra-programmatic publications have increased, to 31% from 29%, and high impact has increased, to 20% from 16%. Prior to the 2018 Program reorganization, our two population science programs had inter-programmatic publication rates of 13% and 19%, which matched the range (13-19%) they reported in 2014. The CPS program leaders have defined program-level and theme-specific plans for future growth. These include enhanced, trans-disciplinary mentorship of junior investigators by senior faculty in multiple disciplines; the development and support of subject workgroups (e.g. obesity, microbiome, breast cancer, tobacco regulatory and geospatial research) to build collaborations that cross the disciplines of population science and beyond; and continued growth of training programs.