Interdisciplinary Mentoring and Research in Womens Cardiovascular Health

心血管疾病(CVD)是女性死亡的主要原因。研究人员和临床医生 能够跨学科边界工作是有效了解、预防和减轻负担所必需的 心脑血管疾病。鉴于女性和心血管疾病的多种性别特有的危险因素，对女性和心血管疾病的关注至关重要 至今仍不完全了解的脑血管病的表现。这份NHLBI职业中期续签申请 以患者为中心的研究中的调查员奖寻求对丽贝卡·瑟斯顿博士的支持，她是一名 在中年女性心血管疾病的跨学科指导、培训和研究方面有良好的记录 健康。该项目的具体目标是为瑟斯顿博士提供培训、资源和保护 是时候加强和放大她的NIH支持的研究项目对公共健康的影响了：(1) 为来自不同领域的年轻研究人员提供出色的指导和支持，以解决问题 对女性心血管健康至关重要；(2)支持瑟斯顿博士和她的培训 受训者(A)高级分析调解方法和(B)选择生理机制(炎症， 表观遗传学)与女性心血管疾病的发展高度相关；以及(3)利用正在进行的NIH RF1- 支持研究，并以K24支持的研究的第一阶段为基础，证明关键 更年期症状(睡眠问题、血管舒缩症状)与颈动脉的横断面关系 动脉粥样硬化中年妇女，传统的心血管疾病危险因素或性激素无法解释的关系。我们 现在将(A)研究更年期症状随着时间的推移与颈动脉粥样硬化之间的关系 及其进展，以及(B)考虑关键的新机制(炎症、表观遗传)途径 严重地将更年期症状与女性的心血管疾病风险联系起来。建议的辅导和职业发展 各项活动是高度一体化的，其目标相辅相成，即促进受训人员的职业生涯和加强 瑟斯顿博士正在开展的女性心血管健康研究和培训项目。

Cardiovascular disease (CVD) is the leading cause of death among women. Researchers and clinicians that can work across disciplinary boundaries are needed to effectively understand, prevent, and reduce the burden of CVD. A focus on women and CVD is critical given the multiple sex-specific risk factors for and manifestations of CVD that remain incompletely understood. This renewal application for an NHLBI Mid-Career Investigator Award in Patient-Oriented Research seeks support for Dr. Rebecca Thurston, an investigator with a strong track record in interdisciplinary mentoring, training, and research in midlife women's cardiovascular health. The specific aims of this Project are to provide Dr. Thurston with the training, resources, and protected time to strengthen and amplify the public health impact of her NIH-supported research program by: (1) providing outstanding mentorship and support for young investigators from diverse fields to address questions of critical importance to women's cardiovascular health; (2) supporting training for Dr. Thurston and her trainees in (a) advanced analytic mediation methods and (b) select physiologic mechanisms (inflammation, epigenetics) highly relevant to the development of CVD in women; and (3) to leverage ongoing NIH RF1- supported research and to build upon the first phase of K24-supported research that demonstrated critical cross-sectional relations of menopausal symptoms (sleep problems, vasomotor symptoms) to carotid atherosclerosis midlife women, relations not explained by traditional CVD risk factors or by sex hormones. We will now (a) investigate how persistence of menopausal symptoms over time relate to carotid atherosclerosis and its progression and (b) consider key novel mechanistic (inflammatory, epigenetic) pathways that may critically link menopausal symptoms to CVD risk in women. Proposed mentoring and career development activities are highly integrated, with the mutually reinforcing goals of advancing trainee careers and enhancing Dr. Thurston's burgeoning program of research and training in women's cardiovascular health.