Small Animal Imaging Shared Resource

西蒙斯综合癌症中心的小动物影像共享资源(SAISR)是 全面的小动物多模式成像资源，促进对 癌症生物学和新疗法的发展。SAISR实现了对肿瘤的非侵入性评估 基于多种成像技术的发展、进展和对治疗的反应，包括光学、 超声波、光声学、核磁共振、CT、SPECT和PET/CT。除了解剖可视化，SAISR 为预后生物标记物和治疗干预提供空间和功能背景。在.之下 在拉尔夫·P·梅森博士的领导下，SAISR促进并整合了病理生理学、新陈代谢和 利用解剖成像识别受体靶标。SAISR为SCCC调查人员提供协助 以及成像技术的非辅助使用、关于最佳成像方法的咨询以及实践 关于使用成像方式的培训。自上次更新以来，SAISR纳入了几个新的 方法，以保持在技术的前沿。基础设施和服务方面的重要改进 能力包括新的光声断层扫描和访问由新的 回旋加速器，提供多种示踪剂，包括18F-MISO、11C-乙酸酯和胆碱，可以用 一台新的Mediso PET/CT扫描仪。核磁共振设施也进行了大幅升级，显著地 扩展新的临床前放射服务，以便研究人员可以使用核磁共振和图像引导放射治疗 在特定的无病原体的隔室内，补充了传统动物收容所的现有仪器 区域。四个SCCC研究项目的41名研究人员利用了SAISR的这些能力 并提供了关键数据和见解，以支持30多个同行审查、资助的成功 自2014年以来，研究项目赠款和119份同行评议出版物，包括在《高影响力》杂志发表的工作 《自然》、《自然通讯》、《自然神经科学》、《临床研究杂志》、 《胃肠病学》和《美国化学学会杂志》。总而言之，SAISR向前推进， 支持并向SCCC社区提供重要的癌症研究成像方式，使他们能够 有效地在体内测试新的治疗策略，并促进临床试验中的配对研究。

The Small Animal Imaging Shared Resource (SAISR) at Simmons Comprehensive Cancer Center (SCCC) is a comprehensive small animal multimodality imaging resource that facilitates advances in the understanding of cancer biology and the development of novel therapeutics. The SAISR enables noninvasive assessment of tumor development, progression, and response to therapy based on multiple imaging technologies, including optical, ultrasound, photoacoustics, MRI, CT, SPECT, and PET/CT. In addition to anatomical visualization, the SAISR provides spatial and functional context for prognostic biomarkers and theranostic interventions. Under the leadership of Ralph P. Mason, PhD, the SAISR facilitates and integrates pathophysiology, metabolism, and receptor target identification with anatomical imaging. The SAISR provides SCCC investigators with assisted and unassisted usage of imaging technologies, consultations on optimal imaging approaches, and hands-on training in the use of imaging modalities. Since the last renewal, the SAISR has incorporated several new approaches in order to stay at the leading edge of technology. Important enhancements in infrastructure and capabilities include new photoacoustic tomography and access to short-lived isotopes generated by a new cyclotron that provides multiple tracers, including 18F-MISO, 11C-acetate, and choline, that can be observed with a new Mediso PET/CT scanner. There have also been substantial upgrades to the MRI facilities that significantly expand the new preclinical radiation services so that investigators can use MRI and image-guided irradiation inside a specific pathogen-free vivarium, complementing the existing instruments in conventional animal housing areas. These capabilities of the SAISR were utilized by 41 investigators across four SCCC research programs in 2019 and provided key data and insights to support the success of more than 30 peer-reviewed, funded research project grants and 119 peer-reviewed publications since 2014, including work published in high-impact journals such as Nature, Nature Communications, Nature Neurosciences, Journal of Clinical Investigation, Gastroenterology, and the Journal of the American Chemical Society. In summary, the SAISR advances, supports, and provides important cancer research imaging modalities to the SCCC community, enabling them to efficiently test new therapeutic strategies in vivo as well as facilitate companion studies in clinical trials.