NHD Permetium Multimodal Imaging System

项目摘要/摘要 这项NIH S10仪器拨款申请的总体目标是申请资金购买一台新的 可用的诺丁山设备(NHD)临床前扫描仪。这一工具将使调查人员能够 史无前例的肺功能和血管变化定量成像破译肺气道病 以及对小动物模型心胸血管重构的评估。这是一种专利澳大利亚人 这项技术也被称为四维X射线测速(4DXV)，是基于风洞技术 被称为粒子图像测速仪，是市场上唯一可以获得超高分辨率的设备 心胸疾病模型的成像和量化。X射线的穿透特性被用来捕获 肺、心脏和相关血管的一系列时间相位对比图像。测速技术被用来 确定解剖结构从一个图像到下一个图像的移动，提供关于这两个图像的信息 运动的速度和方向。图像被配对并离散成小的子区域和交叉区域。 连续图像中的子区域之间执行的相关性。由此产生的4维肺部图像 显示动脉和肺，并提供肺的功能气流和肺血管数据，详细 对呼吸道特定区域的气流和血管系统进行量化。4DX扫描仪提供了一个保险箱， 快速、廉价的工具，不仅可以提供高分辨率图像，还可以生成详细的地区性图像 有关肺功能的信息。 密歇根大学分子成像中心在基础科学和 为整个学术机构提供全面的影像支持 维护一个小型动物成像核心设施，历史上一直专注于癌症模型。增加了 4DXV仪器设备将由一组由NIH资助的、已建立的高级调查人员使用。这个 4DXV临床前扫描仪是心胸外科翻译研究工作中不可或缺的必需品 其中包括对专注于治疗心胸疾病的新型药物的评估。扫描仪 将安置一个完善的动物模型和成像核心，并得到大学的坚定承诺 密歇根分子成像中心建立临床前肺和心脏生理学机构 共享实验室，以确保仪器的长期维护和操作。重要的是，扫描仪 将为肺部研究和诊断提供范式转变。 4DVX是一种很有前途的心胸疾病诊断技术。伊利诺伊大学 密歇根州提供了一个近乎理想的环境，在这个环境中，可以在现有的 小动物成像核心设施。

PROJECT SUMMARY/ABSTRACT The overall objectives of this NIH S10 Instrumentation grant application is to request funds to purchase a newly available Notting Hill Devices (NHD) Preclinical Scanner. This instrument will allow investigators with unprecedented quantitative imaging of lung function and vascular changes for deciphering lung airway disease along with evaluation of cardiothoracic vascular remodeling in small animal models. This patented Australian technology also known as 4-Dimensional X-ray Velocimetry (4DXV) is based on the wind tunnel technology known as particle image velocimetry and is the only commercially available device for ultra-high resolution imaging and quantification of cardiothoracic disease models. The penetrating nature of X-rays is used to capture a series of temporal phase-contrast images of the lungs, heart and associated vascular. Velocimetry is used to determine the movement of an anatomical structure from one image to the next, providing information on both velocity and direction of movement. Images are paired and discretized into small sub-regions and cross- correlations performed between the sub-regions in consecutive images. The resulting 4-dimentional lung images show arteries and lungs and provides functional airflow and pulmonary vasculature data of the lungs with detailed quantification of airflow and vasculature in specific regions of the airways. The 4DX scanner provides a safe, quick, and inexpensive tool that not only provides high-resolution images but also yields detailed, regional information on lung function. The University of Michigan Center for Molecular Imaging has a rich history of contributions in basic science and in medicine and provides overall imaging support to the entire academic institution through establishment and maintenance of a small animal imaging core facility historically focused on cancer models. The addition of the 4DXV instrument equipment will be utilized by a group of NIH-funded, established, senior investigators. The 4DXV Preclinical Scanner is an indispensable necessity for the cardiothoracic translational research efforts which include evaluation of novel classes of drugs focused on treatment of cardiothoracic diseases. The scanner will be housed is a well-established Animal Model and Imaging Core with strong commitment from the University of Michigan Center for Molecular Imaging to establish an institutional Preclinical Lung and Heart Physiology Shared Laboratory to ensure long-term maintenance and operation of the instrument. Importantly, the scanner will provide for a paradigm shift in lung research and diagnostics. 4DVX is a promising and powerful technology for assessment of cardiothoracic diseases. The University of Michigan presents a near ideal environment in which to initiate such a research program within an established small animal imaging core facility.