ShEEP-IC: Request to purchase MAGNETOM Skyra 3T complete concurrent field monitoring and motion correction system upgrade

我们正在申请资金，以购买完整的同步现场监控和运动校正系统 升级我们的Magnetom Skyra 3T扫描仪，预算报价为816,370美元(见 13_VA_附录_3_报价.pdf)。此升级由将使用的两个主要组件组成 同时协同提高扫描的空间分辨率、稳健性和质量。 西门子3T Skyra核磁共振扫描仪升级： Kineticor运动校正系统，KC-3T70(132,500美元) 2.Skope Complete并发监测系统(683 870美元) Kineticor运动校正系统使用低调的四摄像头系统来监控和校正 在MRI扫描采集期间，患者的头部实时运动。这是通过反馈动议来实现的 对扫描仪的估计以更新成像梯度以及由tr在tr上的rf频率和相位 基础。Skope Complete并发监控系统使用16个现场探头来测量和校正 在主磁场中引起动态波动的伪影(例如，由于呼吸、头部运动或其他 磁共振成像系统不完善)。Skope Complete系统包括Neurocam(专用射频磁头线圈 与16个现场探头集成)，以及为用户提供的卡片式摄像机(单独的16个现场探头 希望利用其现有的西门子射频磁头线圈执行并发监控。 关键是，拟议的升级不仅将促进对整个大脑的非侵入性成像 前所未有的空间分辨率，但它也将允许对具有挑战性的患者进行稳健、高质量的成像 人群--包括难以保持静止的人群(例如儿童、老年人和患有神经病的人群 紊乱)以及容易产生生理诱导的图像伪影(例如，大的， 肥胖患者和呼吸模式不规律的人)。因此，现有的研究项目也将 节省时间和成本，因为较少的受试者数据会因不良而丢失或需要重新获取 图像质量。资助这项提议还将极大地加强我们正在进行的招聘高素质人才的努力 学院候选人以及吸引跨机构合作者的努力，这有助于让退伍军人管理局保持在 成像技术开发和临床应用的前沿-最终支持退伍军人 患有疾病的，如神经性(TBI)和精神(PTSD)障碍，对他们来说 诊断工具尚不可用。

We are requesting funds to purchase complete concurrent field monitoring and motion correction system upgrade for our MAGNETOM Skyra 3T scanner at a budgetary quote of $816,370 (see 13_VA_Appendix_3_Quote.pdf). This upgrade comprises of two main components that will be used simultaneously for synergistic improvements to scan spatial resolution, robustness and quality. Upgrades for the Siemens 3T Skyra MRI scanner: 1. Kineticor Motion Correction System, KC-3T70 ($132,500) 2. Skope Complete Concurrent Monitoring System ($683,870) The Kineticor Motion Correction System uses a low profile, quad camera system to monitor and correct for patient head motion in real time during the MRI scan acquisition. This is achieved by feeding back the motion estimates to the scanner to update the imaging gradients as well as RF frequency and phase on TR by TR basis. The Skope Complete Concurrent Monitoring System uses 16 field probes to measure and correct for artifact inducing dynamic fluctuations in the main magnetic field (e.g. due to respiration, head motion, or other MRI system imperfections). The Skope Complete system includes the Neurocam (a dedicated RF head coil integrated with the 16 field probes) as well as the Clip-on Camera (a separate set of 16 field probes) for users who wish to perform concurrent monitoring with their existing Siemens RF head coils. Critically, not only would the proposed upgrade facilitate non-invasive imaging of the whole brain at unprecedented spatial resolutions, but it would also allow for robust, high quality imaging of challenging patient populations - including those who have difficulty keeping still (e.g. children, elderly, and those with neurological disorders) as well as those who are prone to generate physiologically induced image artifacts (e.g. large, obese patients and those with irregular breathing patterns). As such, existing research projects would also reap both time and cost savings since fewer subjects’ data would be lost or need to be re-acquired due to poor image quality. Funding this proposal would also greatly augment our ongoing efforts to recruit high-quality faculty candidates as well as efforts to attract cross-institution collaborators, which help keep the VA at the cutting edge of imaging technology development and clinical applications - ultimately supporting veterans afflicted with disease, such as neurological (TBI) and psychiatric (PTSD) disorders, for whom adequate diagnostic tools are not yet available.