Acquisition of a 7T MR scanner for Translational Imaging Research at Roswell Park

项目摘要 这项S10拨款申请的目的是获得资金，以取代技术上过时的4.7T磁铁 罗斯威尔公园翻译成像共享资源(TISR)的磁共振成像(MRI)扫描仪 综合癌症中心。近二十年来，罗斯威尔公园的TISR一直在提供 向美国国立卫生研究院资助的收费定制科学技术临床前成像服务 罗斯威尔公园、纽约州立大学布法罗分校和邻近学者的调查人员 纽约西部的机构。罗斯威尔公园和UB的50多名教职员工大量使用它 正在进行肿瘤学和放射学的基础和转化性研究。现有的4.7吨磁铁是 通过机构和国家基金的组合购买，是安装在 WNY致力于临床前研究。自2001年以来，TISR已经满足了168名用户的成像需求 其中105例使用了现有的4.7T磁共振扫描仪。然而，这台老化的仪器遇到了两个软 在过去的10年里熄火了，并且有过时的电子产品，缺乏升级能力。这些限制 对NCI唯一指定的综合癌症中心的教职员工和研究项目构成重大风险 位于曼哈顿郊外的纽约州中心。现在20岁的MR的另一个技术故障 扫描仪将是灾难性的，并严重危及NIH/NCI资助的活跃研究的进行 罗斯威尔公园，并阻止我们的教职员工利用MRI进行新的项目，以进行解剖、功能和 癌症的分子成像。因此，购买升级的仪器是一项迫切的需要，不仅将 使TISR既能满足现有的成像技术需求，又能促进TISR的进一步发展。

Project Summary The purpose of this S10 grant application is to secure funding to replace a technically outdated 4.7T magnetic resonance imaging (MRI) scanner for the Translational Imaging Shared Resource (TISR) at Roswell Park Comprehensive Cancer Center. For nearly two decades, the TISR at Roswell Park has been providing customized scientific and technical preclinical imaging services on a fee for service basis to NIH funded investigators at Roswell Park, the State University of New York at Buffalo and neighboring academic institutions in Western New York. It is a heavily utilized by over 50 Roswell Park and UB faculty members who are conducting basic and translational investigations in oncology and radiology. The existing 4.7T magnet was purchased through a combination of institutional and state funds and was the first MR scanner installed in WNY dedicated for preclinical research. Since 2001, TISR has catered to the imaging needs of 168 users, out of whom 105 utilized the existing 4.7T MR scanner. However, this aging instrument has encountered two soft quenches in the last 10 years, and has outdated electronics that lack upgrading capabilities. These limitations pose a significant risk to faculty and research programs at the only NCI designated Comprehensive Cancer Center in the state of New York outside of Manhattan. Another technical failure of the present ~20-year-old MR scanner would be catastrophic and seriously jeopardize the conduct of active NIH/NCI funded research at Roswell Park and prevent our faculty from pursuing new projects utilizing MRI for anatomic, functional and molecular imaging of cancer. Acquisition of an upgraded instrument is therefore a critical need that will not only enable TISR to meet the existing demand for this imaging technology but also facilitate further growth of TISR.