Translational Immunology Training Program

项目总结/摘要 这是一个经过修订的竞争性续订T32应用程序，其中我们合并并重新配置了两个 西奈山伊坎医学院（ISMMS）以前独特而成功的T32项目， 移植免疫学博士后项目[（P Heeger，前项目主任（PD）]和前/博士后 免疫学计划（S里拉，前PD），成为一个扩大的博士前和博士后培训计划， 转化免疫学（P Heeger和S里拉Co-PD）。结合这些方案将a）提高 通过交叉受精（例如，暴露）进行转化免疫学培训（包括移植培训） 癌症免疫学的受训者通过联合移植免疫学、免疫缺陷和自身免疫 培训地点）B）利用共同的培训教师和机构资源，以及修订后的 以免疫学为重点的行政基础设施（包括教育、职业发展和评估 c）限制培训之间的重叠 教师。其他理由包括：1）我们在过去16年中成功地吸引和培训了 博士后MD，PhD和MD/PhD学员进入免疫学研究职业，2）持续需要 改善免疫介导疾病的结果3）我们希望积极影响未来的教育 免疫学的基础和转化研究人员，以及4）我们的培训环境和研究 焦点非常适合为学员提供多样化的基础和转化免疫学研究机会。的 西奈山的免疫学社区的特殊能力，使基本的发现，翻译， 结果纳入新的和有效的诊断和治疗策略，并纳入前和后博士 将培训纳入其研究使命突出了这一修订后的培训方案的重要性。整体 该计划的目标是吸引和培养有才华的MD/PhD和PhD学生和博士后超过2年 期间，成功的，独立的职业生涯在免疫学相关的人类疾病。我们有一个多样化的， 资金充足的教师，对免疫学有广泛的兴趣，以及强大的博士前和博士后培训人员， 包括大量代表性不足的少数群体。该方案旨在通过以下方式提供培训： 在与人类疾病相关的免疫学的各个方面进行研究的个人导师。程序 得到强有力的监督和行政结构的支持，免疫学方面的重要教学培训， 科学写作和职业发展，并包含新增加的最先进的评估方法 有明确的目标和成功的基准，以优化独立学术的发展， 研究人员在该领域。

Project Summary/Abstract This is a revised, competitive renewal, T32 application in which we have coalesced and reconfigured two previously distinct and successful T32 programs at the Icahn School of Medicine at Mount Sinai (ISMMS), a post-doc program in Transplant Immunology [(P Heeger, former program director (PD)] and a pre-/post-doc program in Immunology (S Lira, former PD), into an expanded pre- and post-doctoral training program in Translational Immunology (P Heeger and S Lira Co-PDs). Combining the programs will a) enhance translational immunology training (including training in transplantation) through cross fertilization (e.g. exposing trainees in cancer immunology to transplant immunology, immunodeficiency and autoimmunity through a joint training venue) b) leverage common training faculty and institutional resources, as well as a revised immunology-focused, administrative infrastructure (including education, career development and evaluation processes) to enhance function and efficiency of the training experience, and c) limit overlap among training faculty. Additional rationale include 1) our success over the past 16 years in attracting and training pre- and post-doctoral MD, PhD and MD/PhD trainees into immunology research careers, 2) the continued need for improving outcomes of immune-mediated diseases 3) our desire to positively impact the education of future basic and translational investigators in immunology, and 4) the fact that our training environment and research foci are well-suited to offer diverse basic and translational immunology research opportunities for trainees. The exceptional ability of Mount Sinai's immunology community to make fundamental discoveries, to translate the results into novel and effective diagnostic and therapeutic strategies, and to incorporate pre- and post-doc training into its research mission underscores the significance of this revised training program. The overall objective of this program is to attract and train talented MD/PhD and PhD students and post-docs over 2 year periods, for successful, independent careers in immunology relevant to human disease. We have a diverse, well-funded faculty with broad interest in immunology and a strong pool of pre- and post-doc trainees that includes significant numbers of underrepresented minorities. The program is designed to provide training by individual mentors performing research in all aspects of Immunology relevant to human disease. The program is supported with strong oversight and administrative structure, significant didactic training in Immunology, scientific writing and career development, and contains newly added state of the art evaluation approaches with defined goals and benchmarks for success so as to optimize the development of independent academic researchers in the field.