Division of Cancer Tratment and DIagnosis- Operational Task Order

癌症治疗和诊断部（DCTD）通过加快对新药物、生物标志物、成像检测以及其他诊断和治疗干预（放射、手术、免疫治疗）的初始和后续大规模测试，支持开发新型癌症诊断和治疗方法。 在DCTD中，八个主要项目和一个患者诊所共同努力，将独特的分子，诊断测试和治疗干预从实验室工作台带到患者床边。 该合同支持的活动包括：天然产品的分离和评价;分子药理学;化合物库的高通量筛选;药效学标志物和药代动力学分析的开发和临床试验的利用;药物毒理学研究;信息系统、技术和数据科学;药物发现;放射化学和放射性药物生产;临床试验图像、体外和体内转化研究的存档;天然产品、患者来源的异种移植物、肿瘤和生物抗癌剂的储存库支持;生物制药生产设施;医学作家;为NIH临床中心进行的临床试验提供护理支持服务，与生物制药公司合作进行相关研究;支持精准医学试验;支持临床前模型和临床试验中的肿瘤评估的先进基因组学能力;用于国家癌症研究所资助的临床试验的患者生物储存库;纳米技术表征和评估。

The Division of Cancer Treatment and Diagnosis (DCTD) supports the development of novel diagnostic and therapeutic approaches for cancer by expediting the initial and subsequent large-scale testing of new agents, biomarkers, imaging tests, and other diagnostic and therapeutic interventions (radiation, surgery, immunotherapy) in patients. Within DCTD, eight major programs and a patient clinic work together to bring unique molecules, diagnostic tests, and therapeutic interventions from the laboratory bench to the patient bedside. Activities supported under this contract include: isolation and evaluation of natural products; molecular pharmacology; high-throughput screening of compound libraries; pharmacodynamic marker and pharmacokinetic assay development and utilization in clinical trials; drug toxicology research; information systems, technologies, and data science; drug discovery; radiochemistry and radioactive drug production; archival of clinical trial images, in vitro and in vivo translational research; repository support for natural products, patient-derived xenografts, tumors and biologic anti-cancer agents; a biopharmaceutical production facility; medical writers; nursing support services for clinical trials performed in the NIH Clinical Center, correlative studies in collaboration with biopharmaceutical companies; support for precision medicine trials; advanced genomics capabilities supporting tumor evaluation in pre-clinical models and clinical trials; patient biorepositories for NCI-funded clinical trials; nanotechnology characterization and evaluation.