UAB Nutrition Obesity Research Center (NORC)

我们要求重新提供资金，以继续和扩大UAB营养所取得的成功 肥胖研究中心（NORC）在其前三个资助周期。2000年，我们在NIH的资助下成立， NORC促进多学科，协作，基础，临床和转化营养和肥胖研究。 自从它第一次获得资助以来，NORC的研究基础已经大幅增长。在2000年成立之初，我们 60名成员。到2011年我们最后一次更新时，这一数字已增加到134名成员; 目前有178个成员国。2000年，我们的成员作为PI获得了15个R 01或K-奖项，这些奖项显然与以下方面有关： 营养或肥胖。截至2016年撰写本文时，我们的会员作为PI持有48项R 01、R 00和K奖项，其中包括 明显与营养或肥胖有关。在过去的融资周期中，UAB的NORC直接帮助招募了超过100名 15名新的和建立的肥胖和营养研究人员。我们的出版物产量稳步上升， 绝对数字和占世界肥胖和营养文献的比例。NORC的影响 根据NIH的相对引用率判断，出版物始终超过同行评议文献的标准 在肥胖和营养方面，甚至在NIH资助的研究方面，特别是在50%以上的因素上。我们 NORC领导层负责监督NIH资助的两项用于肥胖研究的T32培训赠款， 正在审查赠款，并打算在下一个供资周期提交第三批赠款。在过去的资助中新发起的 在一个周期内，我们的NORC领导了一系列由国家NIH资助的营养和肥胖相关的年度短期课程 三个新的R25赠款支持。我们的NORC每年至少资助四项试点和可行性研究， 赞助一个新的命名调查员，并实施了广泛的丰富计划。UAB提供我们的 NORC每年超过75万美元，以加强NIDDK P30赠款。NORC的代谢，动物模型， 身体活动和生物统计学核心蓬勃发展，导致成本效益的研究和提高 获得我们的成员大量使用的尖端技术。我们的主题是肥胖： 原因、后果和缓解。在即将到来的周期中，这一广泛领域中的重要子领域 主题将被强调。这些子领域包括：（1）少数民族之间的肥胖和健康差距;（2） 残疾人的肥胖、饮食、减肥和运动;（3）肥胖、精力充沛和衰老;（4） 跨代、发育和儿科方面;（5）数学/定量科学 接近。在卓越的机构支持和学术基础设施的支持下，我们要求重新 继续为这一重要的研究领域做出贡献。

We request renewed funding to continue and expand on the documented success achieved by UAB's Nutrition Obesity Research Center (NORC) in its first three funding cycles. Inaugurated with NIH funding in 2000, our NORC fosters multidisciplinary, collaborative, basic, clinical, and translational nutrition and obesity research. Since it was first funded, the NORC's research base has grown substantially. At its inception in 2000, we had 60 members. By the time of our last renewal in 2011 this number had increased to 134 members; the number today stands at 178 members. In 2000, our members held as PIs 15 R01s or K-awards clearly related to nutrition or obesity. As of this writing in 2016, our members hold as PIs 48 R01s, R00s and K-awards that are clearly related to nutrition or obesity. In the past funding cycle, UAB's NORC has directly helped to recruit over 15 new and established obesity and nutrition investigators. Our publication output has steadily increased in absolute numbers and as a proportion of the world's literature on obesity and nutrition. The impact of NORC publications as judged by NIH’s relative citation ratio consistently exceeds the norm for peer-reviewed literature on obesity and nutrition in general and even for NIH-funded research in particular by a factor of over 50%. Our NORC leadership oversees two NIH-funded T32 training grants for obesity research, has two more training grants in review, and aims to submit a third in the coming funding cycle. Newly initiated in the past funding cycle, our NORC has led a series of national NIH-funded nutrition and obesity-related annual short courses supported by three new R25 grants. Our NORC funds at least four Pilot & Feasibility studies per year, sponsors a Named New Investigator, and implements an extensive Enrichment Program. UAB provides our NORC over $750,000 annually to enhance the NIDDK P30 grant. The NORC’s Metabolism, Animal Models, Physical Activity, and Biostatistics Cores have flourished, resulting in cost-effective research and enhanced access to cutting-edge technology that is heavily utilized by our members. Our primary theme is Obesity: Causes, Consequences, and Alleviation. During the coming cycle, important subdomains within this broad theme will be emphasized. These subdomains include (1) obesity and health disparities among minorities; (2) obesity, diet, weight loss, and exercise among persons with disabilities; (3) obesity, energetics, and aging; (4) transgenerational, developmental, and pediatric aspects; and (5) mathematical/quantitative science approaches. Backed by exceptional institutional support and academic infrastructure, we request renewed funding to continue our contributions to this important area of research.