Enrichment Program

这是科罗拉多州营养肥胖研究中心的5年竞争续订申请 (NORC)。NORC的广泛目标是支持和加强正在进行的营养/肥胖研究，并 促进科罗拉多州NORC成员之间的跨学科协作和垂直整合研究 研究基地。我们现在是我们运营的第20个年头，NORC支持96个常规项目和16个项目 在研究基地指导研究人员，每年产生超过4300万美元的直接成本 营养/肥胖研究。NORC的资源已经被利用来确保超过7000万美元(不是 包括个人研究拨款)，以支持科罗拉多大学的营养/肥胖研究。这个 NORC支持的研究范围从细胞和分子到临床研究再到 社区。我们承诺在我们的研究基地内培养团队科学，因为我们相信 这是我们NORC发展的合乎逻辑的下一步--使用NORC资源来创建和支持 研究团队解决重大而重要的研究问题，这些问题可以通过 跨学科、协作的方法。我们围绕4个研究团队组织了我们的研究基地-1) 肥胖的母婴起源；2)新陈代谢、衰老、性别和锻炼方面的调查(图片)；3) 体重管理；4)肥胖与代谢紊乱。这些团队已经成功地在 为团队科学筹集额外资源。该研究基地由3个科学核心支持 基础、临床和社区研究人员：1)分子和细胞分析；2)能量平衡评估； 3)临床干预和翻译。科罗拉多州北大西洋公约组织在詹姆斯·O·希尔博士的领导下拥有强大的领导力 继续担任NORC主任，Dan Bessesen博士和Paul MacLean博士担任助理 董事们。科罗拉多州NORC位于安舒茨健康和健康中心(AHWC)内，该中心是 位于科罗拉多大学医学院内。AHWC的一项使命是促进研究 翻译和AHWC设施为翻译来自NORC的研究提供了机会。 我们的试点和可行性计划非常成功地帮助我们的新调查人员发展成 独立研究人员和营养/肥胖方面的国家领导者。我们的浓缩计划一直是 成功地帮助促进合作，并使其他卫生保健专业人员和社区富裕起来 在营养和肥胖领域。在它的第二十个年头，科罗拉多州北大西洋公约组织是公认的和良好的 被誉为世界领先的营养与肥胖研究和研究翻译中心之一。

This is an application for a 5 year competitive renewal for the Colorado Nutrition Obesity Research Center (NORC). The broad goal of the NORC is to support and enhance ongoing nutrition/obesity research and to promote interdisciplinary collaborative, vertically integrated research among members of the Colorado NORC research base. We are now in our twentieth year of operation and the NORC supports over 96 regular and 16 mentored investigators in the research base who generate over $43,000,000 per year in direct costs for nutrition/obesity research. The resources of the NORC have been leveraged to secure over $70,000,000 (not counting individual research grants) in support for nutrition/obesity research at the University of Colorado. The research supported by the NORC ranges from cellular and molecular to clinical research to research in the community. We have made a commitment to foster team science within our research base because we believe this is the logical next step in the evolution of our NORC – to use NORC resources to create and support research teams to address big and important research questions that can best be addressed via an interdisciplinary, collaborative approach. We have organized our research base around 4 research team – 1) Maternal-Fetal Origins of Obesity; 2) Investigations in Metabolism, Aging, Gender, and Exercise (IMAGE); 3) Weight Management; 4) Obesity and Metabolic Dysregulation. These teams have already been successful in raising additional resources for team science. The research base is supported by 3 scientific cores that support basic, clinical and community researchers: 1) Molecular & Cellular Analytical; 2) Energy Balance Assessment; 3) Clinical Intervention and Translation. The Colorado NORC has strong leadership with Dr. James O. Hill continuing to serve as NORC Director and Drs. Dan Bessesen and Paul MacLean serving as Associate Directors. The Colorado NORC is located within the Anschutz Health and Wellness Center (AHWC) which is located within the University of Colorado, School of Medicine. A mission of the AHWC is to promote research translation and AHWC facilities provide an opportunity for translation of research emanating from the NORC. Our pilot and feasibility program has been extremely successful in helping develop our new investigators into independent researchers and national leaders in nutrition/obesity. Our enrichment program has been successful in helping promote collaboration and in enriching other health care professionals and the community in the areas of nutrition and obesity. In its twentieth year, the Colorado NORC is well recognized and well respected as one of the leading centers in the world for nutrition and obesity research and research translation.