UAB Nutrition Obesity Research Center (NORC)

UAB NORC产品概要/摘要 我们要求资金继续和扩大UAB的营养肥胖所取得的杰出成就， 研究中心（NORC）在其前四个资助周期，特别是在过去的4年多。落成 2000年，在美国国立卫生研究院的资助下，我们的NORC培养了多学科的、协作的、基础的、临床的和转化的 营养和肥胖研究。NORC的研究基地在数量和生产力上逐渐增长 在前三个融资周期中， 期UAB NORC支持95名正式成员（从63名成员增加）和11名初级成员的研究基地。 成员增长来自1）初级研究人员的成功; 2）其他UAB研究人员的吸引力 研究基地; 3）招募新的研究人员。我们的研究基地产生了超过41，000，000美元（超过 从21，000，000美元）直接资助营养/肥胖研究，并发表了438篇同行评审论文， 过去的融资期。重要的贡献是1）肥胖和代谢失调; 2） 减肥和减肥维持：3）营养和肥胖的精确方法; 4）减少肥胖 在社区; 5）营养，运动，肥胖的残疾人。更令人印象深刻的是 NORC在促进跨学科合作方面的成功，这些合作导致了大量赠款的成功（P 奖）。特别是，慢性病中心（P50）的申请刚刚获得资助， 精准营养临床中心（UO 1）的申请获得了可能成功的优先分数 从2021年底开始融资。这两个大型赠款都广泛使用NORC核心。我们的NORC 支持三个使用良好的核心实验室-代谢，动物模型，行为科学和分析。 前两个核心已经很成熟，第三个核心是从biostats核心发展而来的， 协助不同的研究设计，复杂的数据分析和行为科学。我们的NORC领导 监督三个NIH资助的T32肥胖研究培训赠款。我们的NORC资助了一个成功的试点项目， 可行性计划和赞助一个命名的新研究者。我们的强化计划一直很出色 在吸引顶尖科学家参加我们的系列研讨会和促进研究合作方面。UAB承诺 在未来5年内向NORC提供超过500万美元的资金。在卓越的机构支持和学术支持下， 我们要求重新提供资金，继续为这一重要的研究领域作出贡献。

UAB NORC PROGRAM SUMMARY/ABSTRACT We request funding to continue and expand on the outstanding success achieved by UAB's Nutrition Obesity Research Center (NORC) in its first four funding cycles and particularly during the past 4+ years. Inaugurated with NIH funding in 2000, our NORC fosters multidisciplinary, collaborative, basic, clinical, and translational research in nutrition and obesity. The NORC's research base grew gradually in number and productivity through the first three funding cycles but has achieved explosive growth in funding during the last funding period. The UAB NORC supports a research base of 95 regular members (up from 63 members) and 11 junior members. Growth came from 1) success of junior researchers; 2) attraction of other UAB researchers into the research base; and 3) recruitment of new researchers. Our research base generates over $41,000,000 (up from $21,000,000) in direct funding for nutrition/obesity research and published 438 peer-reviewed papers over the past funding period. Important contributions were made in 1) obesity and metabolic dysregulation; 2) weight loss and weight loss maintenance: 3) precision approaches to nutrition and obesity; 4) reducing obesity in the community; 5) nutrition, exercise, obesity in individuals with disabilities. Even more impressive has been success of the NORC in facilitating interdisciplinary collaborations that have led to success with large grants (P and U awards). In particular, an application for a Chronic Disease Center (P50) was just funded and an application for a Precision Nutrition Clinical Center (UO1) received a priority score that is likely to be successful in funding beginning in late 2021. Both of these large grants extensively use the NORC cores. Our NORC supports three well-used core laboratories – Metabolism, Animal Models, Behavioral Science and Analytics. The first two cores are well-established, and the third core has evolved from a biostats core to add services to assist with different research designs, complex data analysis and behavioral science. Our NORC leadership oversees three NIH-funded T32 training grants for obesity research. Our NORC funds a successful Pilot & Feasibility program and sponsors a Named New Investigator. Our Enrichment Program has been outstanding in bringing top scientists to our seminar series and in facilitating research collaborations. UAB has committed over $5,000,000 to the NORC over the next 5 years. Backed by exceptional institutional support and academic infrastructure, we request renewed funding to continue our contributions to this important area of research.