Nonhuman Primate (NHP) Core Functional Genomics Laboratory for AIDS Vaccine Research and Development

非人灵长类动物（NHP）模型提供了测试各种候选艾滋病疫苗的机会，优化它们引发免疫应答的能力，并测试它们在病毒攻击后预防感染或控制病毒复制的能力。 NIAID为NHP研究提供免疫学和病毒学支持，这些研究在NIAID的猿猴疫苗评估单位（SVEU）合同地点进行，并由艾滋病部（DAIDS）支持的疫苗研究人员通过四个现有的NHP核心实验室（NHP核心实验室）进行：功能基因组学实验室，体液免疫学实验室，细胞免疫学实验室和病毒实验室。NHP核心功能基因组学实验室的目标是确保为SVEU和DAIDS支持的临床前NHP研究进行的功能基因组学服务和测定的标准化和可比性。重要的是，最终目的是在NHP中应用和改进高通量功能基因组学方法，以更有效地评估疫苗诱导的适应性和先天免疫应答以及在攻击/保护研究中的疫苗功效，并鉴定应答（例如，转录组学“标记”），其预测疫苗功效。

Nonhuman primate (NHP) models present the opportunity to test a variety of candidate AIDS vaccines, optimizing their ability to elicit immune responses and testing their ability to prevent infection or to control virus replication after virus challenge. NIAID provides immunological and virological support for NHP studies conducted at NIAID's Simian Vaccine Evaluation Unit (SVEU) contract sites and by Division of AIDS (DAIDS)-supported vaccine researchers through four existing NHP Core Laboratories (NHP Core Labs): the Functional Genomics Lab, the Humoral Immunology Lab, the Cellular Immunology Lab, and the Viral Lab. The NHP Core Functional Genomics Laboratory has the objective of ensuring standardization and comparability of functional genomics services and assays conducted for the SVEU and DAIDS-supported preclinical NHP studies. Importantly, the ultimate aim is to apply and refine high throughput functional genomics approaches in NHPs to more effectively evaluate vaccine-induced adaptive and innate immune responses and vaccine efficacy in challenge/protection studies and identify responses (e.g., transcriptomic "signatures") that predict vaccine efficacy.