UNC MACS/WIHS Combined Cohort Study Clinical Research Site

项目总结/摘要 本申请建议在查佩尔山的北卡罗来纳州大学建立临床研究中心 多中心艾滋病队列研究（MACS）/女性机构间HIV研究（WIHS）合并的研究中心（CRS） 队列研究（MACS/WIHS-CCS）。该提案代表了调查人员之间的合作努力， 全球健康和传染病研究所，艾滋病研究中心，吉林斯学院 全球公共卫生部、Lineberger综合癌症中心、Eshelman药学院和塞西尔 G. Sheps健康服务研究中心。 我们建议尽快建立MACS/WIHS-CCS CRS，为MACS/WIHS做出有意义的贡献- CCS（CCS）统一科学议程，并进行雄心勃勃的研究，包括肺， 心血管、神经认知和其他HIV相关合并症; HIV发病机制/治愈;社会 流行病学和健康结果;行为研究;和先进的流行病学方法。 我们的目标是：（1）招募310名男性和女性参与者，他们反映了美国东南部的艾滋病毒流行情况， 并重新同意当前WIHS参与者参与CCS;（2）领导CCS的关键组成部分 统一科学议程;（3）在CSCCRS上支持CCS科学议程的所有方面。 通过贡献具有代表性的男女人口，创新的科学，以及强大的， 多学科的研究人员骨干，将加强CCS的努力，扩大范围， 可以解决的问题，并与整个小组合作，改善男性的健康， 艾滋病毒感染或高危妇女。

PROJECT SUMMARY/ABSTRACT This application proposes to establish The University of North Carolina at Chapel Hill as a Clinical Research Site (CRS) for the Multicenter AIDS Cohort Study (MACS)/Women’s Interagency HIV Study (WIHS) Combined Cohort Study (MACS/WIHS-CCS). The proposal represents a collaborative effort between investigators from The UNC Institute for Global Health and Infectious Diseases, Center for AIDS Research, UNC Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, Eshelman School of Pharmacy, and Cecil G. Sheps Center for Health Services Research. We propose to rapidly establish the UNC MACS/WIHS-CCS CRS, contribute meaningfully to the MACS/WIHS- CCS (CCS) Unified Science Agenda, and undertake ambitious research that encompasses pulmonary, cardiovascular, neurocognitive, and other HIV-related comorbidities; HIV pathogenesis/cure; social epidemiology and health outcomes; behavioral research; and advanced epidemiologic methods. We aim to: (1) Enroll 310 male and female participants who reflect the HIV epidemic in the southeastern US, and re-consent current WIHS enrollees for participation in the CCS; (2) Lead critical components of the CCS Unified Science Agenda; (3) Support all aspects of the CCS Science Agenda at the UNC CRS. By contributing a representative population of men and women, innovative science, and a strong, multidisciplinary cadre of investigators, UNC will enhance the efforts of the CCS, expand the range of questions that can be addressed and, in collaboration with the entire group, improve the health of men and women with or at high risk for HIV infection.