Affective Sensory Pathways of Light Stroking and Deep Pressure Touch

项目摘要 候选人提出了职业发展独立途径奖，以进一步提升她 在感觉和情感神经科学领域的心理物理和脑成像研究技能。候选人的 最终的职业目标是成为一名独立的、由外界资助的科学家，拥有情感方面的专业知识 躯体感觉及其在补充健康模式中的作用。情感躯体感觉的神经科学是非常重要的 年轻，拥有很大的差距。虽然已知用于轻抚触的情感-感觉传入类型(C低 阈值机械感受器；C-LTMR)，我们还不明白为什么深按压触摸是令人愉快的，而我们理解 对阿片类药物在情感触摸知觉中的作用知之甚少。情感躯体感觉是 多种补充和综合疗法，包括按摩疗法。这项建议的目的是确定 轻抚触和深按压的感觉情感通路接触并决定这些通路的方式和原因 在患有慢性疼痛的个体中不同。该提案的每个目标都得到了课程作业、研究培训的支持 经验、科学会议和研讨会，以及详细的研究计划。 提案的K99期旨在确定深按压触摸的快感是否依赖于 关于肌肉组织中压敏C-LTMR传入的研究以及阿片类药物在快感中的作用 健康个体的轻抚触和深按压触摸。R00周期将决定为什么患有慢性病的个体 疼痛表现为情感感觉加工减少和阿片类药物相互作用改变。本次K99/R00研究的总体目标是 建议是通过以下表现为候选人提供感觉情感神经科学方面的专业知识 在经验丰富的科学家团队的指导下进行心理物理测试和脑成像。候选人是 目前是国家补充和综合健康中心的博士后研究员，她在那里 由M·凯瑟琳·布什内尔博士指导，她是疼痛和情感躯体感觉方面的领先专家，可以访问优秀的 进行神经阻滞、感觉测试和脑成像的设施。K99/R00调查结果 将通过识别轻击和轻击的情感通路来推进情感躯体感觉的神经科学 深按压触摸，使研究这些通路在健康和疾病中的功能以及在各种 补充保健方式，包括按摩。

Project Summary The candidate proposes a career development Pathway to Independence Award to further advance her psychophysical and brain imaging research skills in the area of sensory and affective neuroscience. The candidate's ultimate career goal is to become an independent, extramurally-funded scientist with expertise in affective somatosensation and its role in complementary health modalities. The neuroscience of affective somatosensation is very young and holds large gaps. While an affective-sensory afferent type for light stroking touch is known (the C low threshold mechanoreceptor; C-LTMR), we do not yet understand why deep pressure touch is pleasant, and we understand very little about the role of opioids in affective touch perception. Affective somatosensation is a critical component of numerous complementary and integrative therapies including massage therapy. The purpose of this proposal is to identify the sensory affective pathways of light stroking and deep pressure touch and determine how and why these pathways differ in individuals with chronic pain. Each aim of the proposal is supported by coursework, research training experiences, scientific meetings and seminars, and a detailed research plan. The K99 period of the proposal aims to determine whether the pleasantness of deep pressure touch is dependent on pressure-sensitive C-LTMR afferents in muscle tissue and to determine what role opioids play in the pleasantness of light stroking and deep pressure touch in healthy individuals. The R00 period will determine why individuals with chronic pain show reduced affective sensory processing and altered opioid interactions. The overall goal of this K99/R00 research proposal is to provide the candidate with expertise in sensory affective neuroscience through the performance of psychophysical testing and brain imaging under the guidance of an experienced team of scientists. The candidate is currently a postdoctoral IRTA fellow in the National Center for Complementary and Integrative Health where she is mentored by Dr. M. Catherine Bushnell, a leading expert in pain and affective somatosensation, with access to excellent facilities for conducting nerve blocks, sensory testing, and brain imaging. The findings from the K99/R00 investigations will advance the neuroscience of affective somatosensation by identifying the affective pathways of light stroking and deep pressure touch, enabling research on the functions of these pathways in health and disease as well as in various complementary health modalities including massage.