Affective Sensory Pathways of Light Stroking and Deep Pressure Touch

行政补充建议：摘要 R00 AT009466：轻抚触和深按压触摸的情感感官通路 凯斯博士是加州大学麻醉学系的助理教授 圣地亚哥(加州大学圣地亚哥分校)。在克服了与Covid相关的延误之后，她的R00研究 情感触摸在她目前的SARP中运行顺利并走上了正轨。拟议的行政管理 要求补充两个高度创新的目标，以增加原来的影响 关于建立基于感觉互补的新作用机制的建议研究 推拿疗法等治疗方法。现有的R00研究试图找出钝化的原因 慢性疼痛患者的情感触摸知觉，并比较疼痛缓解机制 轻柔抚触和深按压对纤维肌痛患者和健康人的影响 控制。目前的行政提案增加了两个目标：5)确定 皮下注射OT对实验性疼痛的影响；6)确定皮下注射OT对实验性疼痛的局部影响 触感愉悦。最近对啮齿动物的研究表明，催产素对C纤维有强烈的调节作用 在脊髓和终末轴突。在人类中，全身性催产素调节情感触摸 感觉，皮肤注射可减少术后疼痛。然而，催产素的外周效应对 情感触觉从未在人类身上进行过测试。预计研究结果将显著 对触觉愉悦和外周通路机制的基本理解 减轻疼痛。我们预计这个项目将导致竞争性的R01提交，以测试当地的影响 慢性疼痛患者的催产素含量不同，他们表现出C-伤害性感受器敏化和触摸减少 令人愉快。这一贡献将为后续关于手动触摸疗法机制的研究提供信息 并为测试慢性疼痛患者的差异提供了新的方向。

Administrative Supplement Proposal: Abstract R00 AT009466: Affective Sensory Pathways of Light Stroking and Deep Pressure Touch Dr. Case is as an Assistant Professor in the Department of Anesthesiology at the University of California San Diego (UC San Diego). After overcoming covid-related delays, her R00 study on mechanisms of affective touch is running smoothly and on track with her current SARP. The proposed administrative supplement is requested to add two highly innovative aims to increase the impact of the originally proposed study in establishing novel mechanisms of action for sensory-based complementary approaches such as massage therapy. The existing R00 study seeks to identify factors underlying blunted affective touch perception in individuals with chronic pain, and to compare the pain-relieving mechanisms and effects of light gentle stroking and deep pressure between patients with Fibromyalgia (FM) and healthy controls. The current administrative proposal adds two aims: 5) Determine the local effect of subcutaneous OT on experimental pain and 6) Determine the local effect of subcutaneous OT on touch pleasantness. Recent research in rodents demonstrates that oxytocin strongly modulates C-fibers in the spinal cord and at the terminal axon. In humans, systemic oxytocin modulates affective touch perception, and skin injection reduces postsurgical pain. However, peripheral effects of oxytocin on affective touch perception have never been tested in humans. Study results are expected to significantly impact fundamental understanding of the mechanisms of peripheral pathways for touch pleasantness and pain reduction. We expect this project to lead to a competitive R01 submission to test whether local effects of oxytocin differ in patients with chronic pain, who exhibit C-nociceptor sensitization and reduced touch pleasantness. This contribution will inform subsequent research on mechanisms of manual touch therapies and provide a new direction to test differences in individuals with chronic pain.