University of Washington HUB Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN)

这项建议的目的是通过建立一个大规模的网络， 院前和医院护理，将进行务实的临床试验，解决紧急医疗 影响脑、心脏、肺和/或血液的病症以及危及生命的创伤。这个的组成部分 建议包括国王县紧急医疗服务（KCEMS）与大学合作， 华盛顿及其港景和大学医疗中心。这个“枢纽”将参与这些 临床试验，并提供行政和学术监督和领导其他社区- 在太平洋西北部的设施，和一个额外的学术设施（不列颠哥伦比亚省大学 位于不列颠哥伦比亚省温哥华），该中心将作为进行这些临床试验的招募中心（或“辐条”）。这 提案严格地为这些预期的试验创建网络基础设施，而不是试验本身， 目前尚不清楚。这些试验，当即将到来时，本身将需要独立的监管机构， 预期通过中央机构审查委员会进行的批准，该委员会将在 网络本身已经建立。

The purpose of this proposal is to improve public health through the creation of a large-scale network of prehospital and hospital care that will conduct pragmatic clinical trials addressing emergency medical conditions affecting brain, heart, lung and/or blood as well as life-threatening trauma. The components of this proposal include King County Emergency Medical Services (KCEMS) in concert with the University of Washington and its Harborview and University Medical Centers. This “Hub” will both participate in these clinical trials and provide administrative and academic oversight and leadership over additional community- based facilities in the Pacific Northwest, and an additional academic facility (the University of British Columbia in Vancouver, BC), which will serve as enrolling sites (or “Spokes”) for the conduct of these clinical trials. This proposal strictly creates the network infrastructure for these anticipated trials, and not the trials themselves, which are as yet not known. These trials, when forthcoming, will themselves require independent regulatory approval which is anticipated to occur through a Central Institutional Review Board that will be created once the network itself is established.