Seattle-King County Center for Resuscitation Research

西雅图-金县复苏研究中心

• 批准号: 7276712
• 负责人: Peter James Kudenchuk
• 金额: $ 47.4万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7276712
• 关键词: Admission activity; American Heart Association; Amiodarone; Anti-Arrhythmia Agents; Blood Circulation; Clinical; Clinical Research; Commit; Communities; Conduct Clinical Trials; County; Data; Development; Dextrans; Discipline; Dose; Double-Blind Method; Drug Formulations; Educational process of instructing; Electric Countershock; Emergency medical service; End Point; Enrollment; Environment; Fostering; Heart Arrest; Hospitals; Hypotension; Hypovolemic Shock; Injury; Lidocaine; Life; Link; Liquid substance; Metabolic; Nervous System Physiology; Outcome; Patients; Pharmaceutical Preparations; Pharmacotherapy; Phase; Placebos; Prehospital Emergency Care; Preparation; Protocols documentation; Randomized; Randomized Controlled Clinical Trials; Research; Research Infrastructure; Research Personnel; Research Proposals; Resources; Resuscitation; Role; Saline; Science; Testing; Training; Trauma; Universities; Upper arm; Ventricular Fibrillation; Ventricular Tachycardia; Washington; care systems; design; dextran; experience; improved; insight; mortality; prospective; response; skills; trial comparing

DESCRIPTION (provided by applicant): This application is the response of the University of Washington and Emergency Medical Services (EMS) of Seattle and King County, WA to the RFA HL-04-001 entitled "Clinical Research Consortium to Improve Resuscitation Outcomes." The EMS of Seattle and King County have a programmatic focus on cardiac arrest and life-threatening trauma and continue to make important contributions to each link in the American Heart Association's "chain of survival," as well as important advances in trauma management. An experienced group of internationally renown investigators, along with the infrastructure and resources provided by the University with broad community support, are committed to advancing resuscitation science through the training of young investigators in the field of prehospital emergency care and the conduct of clinical trials. This application sets forth 2 research proposals pertaining to management of out-of-hospital cardiac arrest, and life-threatening trauma that exemplify the insights and expertise of the assembled team of researchers and the quality of the local prehospital care system. The cardiac arrest proposal is a prospective, randomized, double-blind comparison of amiodarone, lidocaine and placebo in out-of-hospital ventricular fibrillation that will assess the impact of such treatment on neurologically functional survival. The trauma protocol is a similarly designed comparison of 7.5% hypertonic saline in dextran, 3% saline, and conventional fluid resuscitation on mortality and neurologic function after blunt traumatic injury associated with hypovolemic shock. Each proposal will enroll between 400-500 patients over a two year period, and will have enhanced statistical power to establish their important endpoints through participation of a Consortium of clinical research centers. Finally, a Clinical Research Skills Development Core is proposed, founded on the rich research and teaching environment of the University and prehospital care system to foster and direct the training of young investigators from a variety of disciplines in resuscitation research.

描述(由申请人提供)： 该申请是华盛顿州西雅图和金县的华盛顿大学和紧急医疗服务(EMS)对RFA HL-04-001名为“改善复苏结果的临床研究联盟”的回应。西雅图和金县的EMS将重点放在心脏骤停和危及生命的创伤上，并继续为美国心脏协会“生存链”中的每一个环节做出重要贡献，以及在创伤管理方面取得重要进展。一个经验丰富的国际知名研究人员小组，以及大学在社区广泛支持下提供的基础设施和资源，致力于通过培训院前紧急护理领域的年轻研究人员和进行临床试验来促进复苏科学的发展。本申请提出了2项研究建议，涉及院外心脏骤停和危及生命的创伤的管理，体现了聚集的研究团队的洞察力和专业知识，以及当地院前护理系统的质量。心脏骤停的建议是对院外室颤患者的胺碘酮、利多卡因和安慰剂进行前瞻性、随机、双盲比较，以评估此类治疗对神经功能生存的影响。创伤方案是一项类似设计的比较，包括7.5%高渗盐水右旋糖酐、3%生理盐水和常规液体复苏对钝性创伤合并低血容量性休克后死亡率和神经功能的影响。每项提案将在两年内招募400-500名患者，并将增强统计能力，通过临床研究中心联盟的参与来确定他们的重要终点。最后，建议建立一个临床研究技能发展核心，建立在大学丰富的研究和教学环境和院前护理系统的基础上，培养和指导来自不同学科的年轻研究人员在复苏研究方面的培训。