Seattle-King County Center for Resuscitation Research

西雅图-金县复苏研究中心

• 批准号: 7468351
• 负责人: Peter James Kudenchuk
• 金额: $ 38.71万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7468351
• 关键词: Admission activity; American Heart Association; Amiodarone; Anti-Arrhythmia Agents; Blood Circulation; Clinical; Clinical Research; Commit; Communities; Conduct Clinical Trials; County; Data; Development; Dextrans; Discipline; Dose; Double-Blind Method; Drug Formulations; Educational process of instructing; Electric Countershock; Emergency medical service; End Point; Enrollment; Environment; Fostering; Heart Arrest; Hospitals; Hypotension; Hypovolemic Shock; Injury; Lidocaine; Life; Link; Liquid substance; Metabolic; Nervous System Physiology; Outcome; Patients; Pharmaceutical Preparations; Pharmacotherapy; Phase; Placebos; Prehospital Emergency Care; Preparation; Protocols documentation; Randomized; Randomized Controlled Clinical Trials; Research; Research Infrastructure; Research Personnel; Research Proposals; Resources; Resuscitation; Role; Saline; Science; Testing; Training; Trauma; Universities; Upper arm; Ventricular Fibrillation; Ventricular Tachycardia; Washington; care systems; design; dextran; experience; improved; insight; mortality; prospective; response; skills; trial comparing

DESCRIPTION (provided by applicant): This application is the response of the University of Washington and Emergency Medical Services (EMS) of Seattle and King County, WA to the RFA HL-04-001 entitled "Clinical Research Consortium to Improve Resuscitation Outcomes." The EMS of Seattle and King County have a programmatic focus on cardiac arrest and life-threatening trauma and continue to make important contributions to each link in the American Heart Association's "chain of survival," as well as important advances in trauma management. An experienced group of internationally renown investigators, along with the infrastructure and resources provided by the University with broad community support, are committed to advancing resuscitation science through the training of young investigators in the field of prehospital emergency care and the conduct of clinical trials. This application sets forth 2 research proposals pertaining to management of out-of-hospital cardiac arrest, and life-threatening trauma that exemplify the insights and expertise of the assembled team of researchers and the quality of the local prehospital care system. The cardiac arrest proposal is a prospective, randomized, double-blind comparison of amiodarone, lidocaine and placebo in out-of-hospital ventricular fibrillation that will assess the impact of such treatment on neurologically functional survival. The trauma protocol is a similarly designed comparison of 7.5% hypertonic saline in dextran, 3% saline, and conventional fluid resuscitation on mortality and neurologic function after blunt traumatic injury associated with hypovolemic shock. Each proposal will enroll between 400-500 patients over a two year period, and will have enhanced statistical power to establish their important endpoints through participation of a Consortium of clinical research centers. Finally, a Clinical Research Skills Development Core is proposed, founded on the rich research and teaching environment of the University and prehospital care system to foster and direct the training of young investigators from a variety of disciplines in resuscitation research.

描述（由申请人提供）： 本申请是华盛顿大学和华盛顿州西雅图和金县的紧急医疗服务（EMS）对RFA HL-04-001（标题为“改善复苏结局的临床研究联盟”）的回应。“西雅图和金县的EMS有一个计划重点是心脏骤停和危及生命的创伤，并继续为美国心脏协会的“生存链”中的每个环节做出重要贡献，以及创伤管理的重要进展。 一组经验丰富的国际知名的研究人员，沿着由大学提供的基础设施和资源与广泛的社会支持，致力于通过在院前急救护理和临床试验的进行领域的年轻研究人员的培训，以推进复苏科学。 本申请提出了2项研究建议，涉及院外心脏骤停和危及生命的创伤的管理，这些建议体现了研究人员组成的团队的见解和专业知识以及当地院前护理系统的质量。 心脏骤停方案是一项前瞻性、随机、双盲比较胺碘酮、利多卡因和安慰剂治疗院外室颤的研究，旨在评估此类治疗对神经功能生存率的影响。 创伤方案是一项类似设计的比较，在与低血容量性休克相关的钝性创伤后，7.5%高渗盐水的右旋糖酐、3%盐水和常规液体复苏对死亡率和神经功能的影响。 每项提案将在两年内招募400-500名患者，并将通过临床研究中心联盟的参与增强统计能力，以确定其重要终点。 最后，提出了一个临床研究技能发展的核心，建立在大学和院前护理系统丰富的研究和教学环境，以促进和指导复苏研究的各种学科的年轻研究人员的培训。