Training program in the neurology of language and neurodegenerative aphasias

本次K24助学金续期是为了支持玛丽亚·路易莎·戈尔诺·坦皮尼博士的辅导活动。 行为神经学家和认知神经学家。戈尔诺·坦皮尼博士是一位领先的研究员和临床医生 神经学和语言神经科学领域，具有非典型神经退行性变方面的专门知识 表现为言语和语言障碍的疾病。她指导了一群才华横溢的临床医生 研究人员研究和治疗原发性进行性失语症(PPA)，并调查语言的神经基础。 戈尔诺·坦皮尼博士在指导临床医生和科学家治疗患者-- 与语言障碍相关的定向研究(POR)。 这项提案的目标是支持戈尔诺·坦皮尼博士有时间指导越来越多的 不同的临床医生和研究人员对神经退行性语言障碍感兴趣，以扩大她的影响 作为加州大学旧金山分校的导师，并在PPA追求新的研究路线。利用可在 加州大学旧金山分校记忆和衰老中心(MAC)、全球脑健康研究所和加州大学旧金山分校临床和 她将指导临床医生、教师、博士后学者和科学家 特别注意在她的实验室、大学和 整个职业。她将维持她的全面指导系统，以一对一指导为特色， 监督临床医生对病人的诊断和护理，以及小组辅导活动。她将更新和扩展 该系统有机会与同事一起接受语音和数据科学方面的培训，并专注于指导 更高级的初级同事本身就是新兴的导师。Gorno Tempini博士在BASIC方面的经验 认知神经科学和神经学方法论以及她日益微妙的领导专长 她的独特定位使她受益于不同的受训者群体。 本文提出的研究项目将开发自动、高效、客观的语音测量方法 按购买力平价生产。这项研究将把声学分析脚本和自动语音识别应用到五个 从500名特征良好的PPA患者那里收集的几分钟录音，并使用动态语音 MRI用于识别与语音发音错误相对应的声道运动的解剖生物标记物。这 将导致更早地发现言语缺陷；改善临床症状的特征；以及更多 详细、客观和有效的成果衡量标准，以跟踪进展情况，并在未来对 治疗。通过其他MAC收集的声学测量和成像数据的机器学习分析 这些项目将为身体病理的预测提供新的工具，并为神经基础提供新的知识 说话的方式。 这笔赠款将有助于支持戈尔诺·坦皮尼博士实现指导下一个目标的目标 一代神经病学临床科学家研究语言和神经退行性失语症。

This K24 grant renewal is requested to support the mentoring activities of Dr. Maria Luisa Gorno Tempini, a behavioral neurologist and cognitive neuroscientist. Dr. Gorno Tempini is a leading researcher and clinician in the fields of neurology and the neuroscience of language, with specific expertise in atypical neurodegenerative diseases that present as speech and language disorders. She mentors a talented group of clinicians and researchers to study and treat Primary Progressive Aphasia (PPA) and investigate the neural basis of language. Dr. Gorno Tempini has a proven track record of success in mentoring both clinicians and scientists in patient- oriented research (POR) related to speech and language disorders. The goals of this proposal are to support time for Dr. Gorno Tempini to mentor a growing number of increasingly diverse clinicians and researchers interested in neurodegenerative language disorders, to extend her impact as a mentor at UCSF, and to pursue novel lines of research in PPA. Leveraging the resources available at the UCSF Memory and Aging Center (MAC), the Global Brain Health Institute, and the UCSF Clinical and Translational Science Institute, she will mentor clinicians, faculty, postdoctoral scholars, and scientists with particular attention to cultivating diversity, equity, and inclusion in her laboratory, the university, and the profession at large. She will sustain her comprehensive mentoring system that features one-on-one mentoring, supervision of clinicians in patient diagnosis and care, and group mentoring activities. She will update and extend that system with opportunities for training with colleagues in speech and data science and a focus on mentoring more advanced junior colleagues as emerging mentors themselves. Dr. Gorno Tempini's experience in basic cognitive neuroscience and neurological methodologies and her increasingly nuanced leadership expertise uniquely position her to benefit a diverse group of trainees. The research project proposed here will develop automatic, efficient, and objective methods to measure speech production in PPA. The study will apply acoustic analysis scripts and automatic speech recognition to five minutes of audio recordings collected from 500 well-characterized PPA patients and employ dynamic speech MRI to identify anatomical biomarkers of vocal tract movements corresponding to speech articulation errors. This will lead to earlier detection of speech deficits; improved characterization of clinical syndromes; and more detailed, objective, and efficient outcome measures to track progression and, in the future, response to treatment. Machine learning analyses of acoustic measures and imaging data collected through other MAC projects will provide novel tools for prediction of post-mortem pathology and new knowledge on the neural basis of speech. This grant will be instrumental in supporting the pursuit of Dr. Gorno Tempini's goals to mentor the next generation of clinician scientists in the neurology of language and neurodegenerative aphasias.