2021 Wnt Signaling GRC/GRS

项目摘要 我们请求为戈登研究会议(GRC)和戈登研究研讨会(GRS)提供部分支持 题为《Wnt信号：分子机制、发育和组织动态平衡与治疗》 2021年8月1日至6日在西班牙卡斯特尔德费尔斯的Rey Don Jaime Grand酒店举行。本次会议将由 斯蒂芬·安格斯(加拿大多伦多大学)和玛丽安·比恩茨(MRC，英国)与肯·卡迪根 美国密歇根大学)和马德隆·莫里斯(荷兰乌得勒支大学)担任副主席，并将包括 来自许多杰出科学家的演讲，在不同的职业阶段，活跃在WNT生物学领域。这个 GRS将于2021年7月31日至8月1日在同一地点举行，届时将有来自应届毕业生的演讲 学生和博士后研究员，将由博士后研究员Rony Chadiac(多伦多大学)领导 和Pooja R.Sonavane(USCD)。会议的具体目的是为演讲提供一个论坛。 并讨论了WNT生物学各方面的最新进展和新观点。这一领域的进展已经 一直在加速，并触及了所有后生动物生命形式中无数的生物过程。在……里面 此外，Wnt途径被广泛认为是组织动态平衡的关键调节因子，因此， 它的去调节与许多疾病有关，从早期发育异常到年龄相关。 疾病，如癌症。 会议主题的选择是基于它们对当前关键科学问题的潜在影响 在发育中，干细胞生物学和癌症。会议的结构包括关于这些机制的会议 Wnt信号转导、Wnt信号的结构和功能、Wnt信号在组织工程中的应用 有机化合物，疾病中的Wnt信号，发育中的Wnt信号，bcatenin非依赖的Wnt信号 干细胞中的信号、组织动态平衡和再生以及Wnt信号的治疗靶向。真知灼见 将从广泛的模式生物中收集到WNT功能，包括九头蛇、蠕虫、苍蝇、 青蛙、鱼和老鼠。聚集在这次会议上的科学家的多样性以及广泛的主题 不仅将提供一个丰富的学习环境，肯定会使所有与会者受益，而且还将导致 新的洞察力、互动和未来的合作将推动生物医学研究的边界。 GRC的主要长期目标是提高我们对这一复杂而关键的信号通路的理解 并因此有助于不断开发针对和操纵这一途径的方法 对目前不治之症的最终治疗干预。

Project Summary We request partial support for the Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) titled ““Wnt Signaling: Molecular Mechanisms, Development andTtissue Homeostasis, and Therapeutics” to be held August 1-6, 2021 at the Rey Don Jaime Grand Hotel in Castelldefels, Spain. This meeting will be chaired by Stephane Angers (University of Toronto, Canada) and Mariann Bienz (MRC, UK) with Ken Cadigan (University of Michigan, USA) and Madelon Maurice (UMC Utrecht, Netherlands) as Vice-Chairs., and will include presentations from many prominent scientists, at varied career stages, active in the field of Wnt biology. The GRS will be held at the same location July 31-August 1, 2021 and will feature talks from up and coming graduate students and postdoctoral fellows and will be led by postdoctoral fellows Rony Chidiac (University of Toronto) and Pooja R. Sonavane (USCD). The specific aim of the conference is to provide a forum for the presentation and discussion of recent advances and new ideas in all aspects of Wnt biology. Progress in this field has consistently accelerated and has touched on countless biological processes in all metazoan life forms. In addition, the Wnt pathway is widely recognized as a critical regulator of tissue homeostasis, and, consequently, its de-regulation is associated with many disorders, from early developmental abnormalities to age-related diseases, such as cancer. Session topics have been selected on the basis of their potential impact on the key current scientific questions in development, stem cell biology and cancer. The meeting is structured to include sessions on the mechanisms of Wnt signal transduction, structure and function of Wnt signaling, Wnt signaling in tissue engineering and organoids, Wnt signaling in diseases, Wnt signaling in Development, bcatenin-independent Wnt signaling, Wnt signaling in stem cells, tissue homeostasis and regeneration and Therapeutic targeting of Wnt signaling. Insights into the Wnt function will be gleaned from a broad spectrum of model organisms, including hydra, worms, flies, frogs, fish and mice. The diversity of scientists gathering at this meeting along with the broad spectrum of topics will not only provide a fertile learning environment that will certainly benefit all attendees, but will also lead to new insights, interactions and future collaborations that will push the boundaries of biomedical research. The main long-term goal of this GRC is to raise our understanding of this complex and critical signaling pathway and thereby contribute to the continuous development of methods to target and manipulate this pathway for eventual therapeutic interventions of currently incurable diseases.