Conduct of studies to evaluate the subchronic and developmental neurotoxicity of isopropylated phenol phosphate in rats (after perinatal exposure) for the National Toxicology Program (NTP)

该项目的目标是为国家毒理学计划（NTP）的危害识别活动提供支持，旨在预防因环境暴露于化学或物理剂而引起的疾病或不良影响。毒性试验是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的毒理学研究，以确保得出的数据可靠。本项目涉及通过给药饲料接触金属钨和磷酸异丙基苯酚对大鼠的毒性研究；暴露发生在妊娠期和哺乳期以及断奶后三个月。磷酸异丙基苯酚是一种芳香型有机磷酸盐阻燃剂。由于这类阻燃剂正在取代其他类别的阻燃剂，预计会增加使用。一般人群通过其在消费品和环境中的存在而接触到异丙基磷酸苯酚。该项目的数据将用于制定关于钨金属和亚氧化物纤维对大鼠和小鼠潜在毒性的合理科学结论，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，公众可充分了解因接触不同形式的钨而产生的风险因素。

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of tungsten metal and isopropylated phenol phosphate in rats, following exposure via dosed feed; exposures occur during gestation and lactation and for three months after weaning. Isopropylated phenol phosphate is an aromatic organo phosphate flame retardant. Increased use is anticipated as this class is replacing other classes of flame retardants. Exposure to isopropylated phenol phosphate occurs in the general population via its presence in consumer products and in the environment. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of tungsten metal and suboxide fibers in rats and mice and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to different forms of tungsten. Keywords: toxicity, isopropylated phenol phosphate, dosed feed, flame retardant