Gene regulation by retroelement encoded natural antisense transcripts

遗传信息是地球上所有生命的基础，并被加工成蛋白质，这些蛋白质决定了有机体的特征。然而，在我们的整个基因组中，只有大约2%是由编码蛋白质的基因组成的；其余98%是非编码的，其功能仍然知之甚少。目的和意义：这项提议旨在利用尖端基因组技术来产生关于非编码基因组如何调节蛋白质编码基因表达的新知识。预期结果和好处：这项提议将为基因调控提供新的目标和方法，从生物学到环境科学都有广泛的应用。

Genetic information underpins all life on earth and is processed to make proteins, which determine the characteristics of an organism. However, only about 2% of our whole genome is made up of genes that encode proteins; the other 98% is non-coding and its function remains poorly understood. Aims and Significance: This proposal aims to utilise cutting edge genomic technologies to generate new knowledge about how the non-coding genome regulates the expression of protein coding genes. Expected Outcomes and Benefits: This proposal will provide novel targets and methodology for gene modulation with broad applications from biology to environmental sciences.