TRACER Developmental Research Program

实验研究：项目总结 P20肺癌转化研究中心的发展研究项目（DRP） 差异（TRACER）应用程序旨在选择和支持非常有前途和创新的试点研究 减少肺癌健康差距的项目。TRACER MPI和DRP领导层（代表3个 参与国家癌症研究所指定的癌症中心在弗吉尼亚联邦大学，医学 南卡罗来纳州大学和City of Hope）为试点研究项目的选择设定了明确的优先事项。 这些优先事项是（1）展示特殊转化科学潜力的项目，（2）包容性项目 3个参与机构之间的纵向和横向合作，以及（3）项目最大 对弗吉尼亚州、南卡罗来纳州和南加州的不同社区的影响。这些试点 研究项目可能包括使用人体样本的基础研究探索，诊断或治疗临床 临床试验形式的干预措施或基于社区的预防干预措施。的主要优点 这三个机构的P20跟踪合作是，它提供了直接访问不同的城市和农村 种族/民族构成以及文化和环境特征差异很大的地区， 可能导致肺癌中报道的差异（例如，大量的非洲裔美国人/黑人 弗吉尼亚州和南卡罗来纳州以及加州南部的大量西班牙裔/拉丁裔和亚裔人群，发生率较高 弗吉尼亚州和南卡罗来纳州的吸烟率;加州南部的空气污染水平很高）。DRP将提供 直接和重大的财政支持，以竞争性选择的试点研究项目，并将提供这些 试点项目的主要研究人员或调查小组，可利用追踪和评估方案支助的 核心资源和三个参与机构内可利用的其他尖端资源的特别清单。 DRP的领导人每年将选择并资助至少3个试点研究项目， 将由内部和外部的科学和社区顾问在多个层面仔细监测进展情况。 DRP的最终目标是建立一个研究管道，专注于多维度的原因， 合作机构所服务的不同人群中的肺癌差异，并制定 初步数据，以支持未来的竞争性研究项目，合作P50孢子应用。

DEVELOPMENTAL RESEARCH PROGRAM: PROJECT SUMMARY The Developmental Research Program (DRP) within this P20 Translational Research Center in Lung Cancer Disparities (TRACER) application aims to select and support highly promising and innovative pilot research projects to reduce health disparities in lung cancer. The TRACER MPI and DRP leadership (representing the 3 participating National Cancer Institute-designated cancer centers at Virginia Commonwealth University, Medical University of South Carolina, and City of Hope) have set clear priorities for the selection of pilot research projects. These priorities are (1) projects demonstrating exceptional translational science potential, (2) projects inclusive of vertical and horizontal collaborations between the 3 participating institutions, and (3) projects with maximum impact on the diverse communities serving—Virginia, South Carolina, and southern California. These pilot research projects may include basic research explorations using human samples, diagnostic or treatment clinical interventions in the form of clinical trials, or community-based prevention interventions. A major advantage of this 3-institution P20 TRACER collaborative is that it provides immediate access to distinct urban and rural regions with vastly different racial/ethnic compositions as well as cultural and environmental characteristics that likely contribute to the disparities reported in lung cancer (e.g., large African American/Black populations in Virginia and South Carolina and large Hispanic/LatinX and Asian populations in southern California, high rates of smoking in Virginia and South Carolina; high levels of air pollution in southern California). The DRP will provide direct and significant financial support for competitively selected pilot research projects and will provide these pilot project PIs or investigative teams with access to the expertise and resources of the TRACER-supported cores and an extraordinary list of other cutting-edge resources available within the 3 participating institutions. The leaders of the DRP will select and fund a minimum of 3 pilot research projects annually, and the projects’ progress will be carefully monitored by multi-levels of internal and external scientific and community advisors. The ultimate goal of the DRP is to establish a pipeline of research focused on the multi-dimensional causes of lung cancer disparities within the diverse populations served by the partnering institutions and to develop the preliminary data to support competitive research projects for a future, collaborative P50 SPORE application.