Core 4: Shared Resource - Capacity Development

建立成功的研究合作是一项具有挑战性的工作。成功的合作更具挑战性 在跨机构和与早期调查人员(ESIS)合作时。为了克服这些挑战，我们 开发了能力建设核心。核心的目标是提供资源和指导，以建立联合 希望之城综合癌症中心(CoHCCC)与加州大学的合作 河滨大学(UCR)ESI。我们的目标是建立合作，1)提高UCR在药物开发方面的能力 能力--在药物开发流水线的所有阶段，以及2)产生独立的NIH资金。容量 CORE将把UCR esis与CoHCCC和UCR的高级调查人员进行匹配。CoHCCC高级调查人员将 根据他们之前被证明的能力被选中，1)成功地指导Esis，2)帮助他们获得独立 国家卫生研究院的资助。U54派、欧内斯特·马丁内斯博士(UCR)和维多利亚·西沃特(CoH)拥有广泛的导师关系 拥有丰富的经验并将领导能力核心。根据能力核心，UCR-COH迷你飞行员将由1)由 Esis在高级导师的指导下，2)参加比赛，3)团队获得10万美元的奖励，为期一年。我们的P20计划 格兰特告诉我们，当ESI有来自CoH和CoH的高级导师时，试点项目的成功会增加 因此，申请迷你飞行员的UCR ESI必须有COH和UCR导师。在第一年和 2每年将资助3个迷你飞行员。这6个迷你飞行员将是我们建立 UCR ESI-COH联合赠款和UCR的能力。在3-5年内，最初分配给该容量的200,000美元 建筑核心，将被重新分配来支持两个新的飞行员-飞行员3和4。在3-5年，我们将提供1个迷你- 试点/年。COH可自由支配资金(100,000美元/年)将使我们能够补充试点项目或增加 3-5年级提供的迷你飞行员数量。

It is challenging to build successful research collaborations. Successful collaborations are even more challenging when working across institutions and with early-stage investigators (ESIs). To overcome these challenges, we developed the Capacity Building Core. The Core's goal is to provide resources and mentorship to build joint collaborations between City of Hope Comprehensive Cancer Center (CoHCCC) and University of California, Riverside (UCR) ESI. We aim to build collaborations that 1) increase UCR capacity for drug development capacity - at all stages of the drug-develop pipeline and 2) result in independent NIH-funding. The Capacity Core will match UCR ESIs with senior CoHCCC and UCR investigators. Senior CoHCCC investigators will be selected based on their prior proven ability to 1) successfully mentor ESIs and 2) help them attain independent NIH funding. U54 PI, Drs. Ernest Martinez (UCR) and Victoria Seewaldt (CoH) have extensive mentorship experience and will lead the Capacity Core. Under the Capacity Core, UCR-CoH Mini-Pilots will be 1) crafted by ESIs under senior mentorship, 2) competed, and 3) teams awarded $100,000 for one year. Our P20 planning grant shows us that success of a pilot project is increased when ESI have senior mentors from both CoH and UCR; therefore UCR ESI applying for Mini-Pilots are required to have a CoH and UCR mentor. In Years 1 and 2 a total of 3 Mini-Pilots will be funded/year. These 6 Mini-Pilots will be an important opportunity for us to build joint UCR ESI-CoH grants and capacity at UCR. In Years 3-5, $200,000 originally allocate to the Capacity Building Core, will be re-allocated to support two new Pilots – Pilots 3 and 4. In Years 3-5, we will offer 1 Mini- Pilot/year. CoH discretionary funds ($100,000/year) will allow us to either supplement Pilot Projects or increase the number of Mini-Pilots offered in Years 3-5.