GPR55 receptor signaling in binge alcohol drinking behavior

项目摘要 酗酒，特别是酗酒（乙醇）是一个主要的公共卫生问题。最近 研究表明，青少年和年轻人酗酒的流行率很高。像大多数 滥用药物，乙醇的使用通常是在青春期开始，导致短期和长期的 负面健康后果，包括酒精使用障碍（AUD）发展的风险增加。 虽然在理解AUD的神经生物学方面已经取得了重大进展，但 酗酒对大脑和神经机制的影响导致行为缺陷， 明白了最近的研究表明，孤儿G蛋白偶联受体55（GPR 55） 信号传导在健康和疾病中发挥着重要作用。然而，GPR 55信号在暴食中的作用 目前还不清楚饮酒情况。这项研究的重点是了解暴饮暴食的影响 在青春期和成年早期饮酒对大脑GPR 55信号传导的影响，并评估药物是否 使用C57 BL/6 J小鼠模型，靶向GPR 55调节酒精狂饮。本研究将提供 进一步深入了解酗酒的神经机制，这一发现将有助于 开发有效的AUD治疗干预措施。

Project Summary Alcohol abuse, particularly binge alcohol (ethanol) drinking, is a major public health concern. Recent studies have revealed a high prevalence of binge drinking in adolescence and young adults. Like most drugs of abuse, ethanol use is usually initiated in adolescence leading to short-term as well as long-term negative health consequences, including increased risk for the development of alcohol use disorder (AUD). Although significant advances have been made in understanding the neurobiology of AUD, the effect of binge drinking on the brain and neuronal mechanisms contributing to the behavioral deficits are not yet clearly understood. Recent studies have suggested that an orphan G-protein-coupled receptor 55 (GPR55) signaling plays an important role in health and diseases. However, the role of GPR55 signaling in binge alcohol drinking is currently unknown. The proposed research is focused on understanding the effects of binge alcohol drinking in both adolescence and young adulthood on brain GPR55 signaling, and assess if the drugs targeted to GPR55 regulate binge ethanol drinking using a C57BL/6J mouse model. This study will provide further insight into neuronal mechanism of binge alcohol drinking, and the findings would assist in the development of effective therapeutic interventions for AUD.