Modeling and Theory

概要/摘要-项目5。建模与理论 这个合作项目将开发综合的多尺度模型，将来自所有项目的数据纳入其中， Berghia大脑项目描述了感官输入是如何表现和影响行为的。它将提供 数据分析和建模框架，其中综合从连接组学分析收集的信息， 行为分析和大规模神经活动记录。网络活动沿着行为分析 输出将减少到分层低维系统。将开发新的方法来分析 连接组学数据富含额外的特征，包括来自基因分析的分子信息 表情具体来说，该项目旨在确定外周神经进行什么处理 神经丛，这些如何直接影响行为，这种处理的计算机制是什么 以及这些处理过程是如何与中央大脑相互作用的。三位合作研究者带来了互补的 专业知识，并将相互密切互动，并与实验小组朝着发展， 一个综合的模型和识别的解释性和解释性的计算算法。

SUMMARY/ABSTRACT – Project 5. Modeling and Theory This collaborative project will develop integrative, multi-scale models that incorporate data from all Projects in the Berghia Brain Project to describe how sensory inputs are represented and influence behavior. It will provide data analysis and modeling frameworks in which to synthesize information gathered from connectomics analysis, behavioral analysis, and large-scale neural activity recordings. Analysis of network activity along with behavioral outputs will be reduced to hierarchical low-dimensional systems. Novel methods will be developed to analyze connectomic data enriched with additional features including molecular information from analysis of gene expression. Specifically, the Project aims to determine what processing is carried out by the peripheral nerve plexuses, how these may influence behavior directly, what are the computational mechanisms of this processing and how such processing interfaces with the central brain. The three co-investigators bring complementary expertise and will interact closely with one another and with the experimental groups toward the development of an integrated model and the identification of interpretative and explanatory computational algorithms.