Patient oriented research and mentoring program in dermatologic diseases

摘要 此K24续订申请的总体目标是继续为Maryam Asgari医学博士、公共卫生硕士提供 受保护的时间作为初级临床研究人员的导师，并支持新的科学目标 建立在Asgari博士以病人为导向的皮肤病研究的基础上。阿斯格里博士是一位 国家认可的皮肤流行病学家、莫氏外科医生和以患者为中心的主任 哈佛医学院皮肤病(毛孔)流行病学研究。她是校长 几个以患者为导向的大型研究的调查者，包括两个由NIH资助的R01检查 影响皮肤癌发展的遗传和环境因素。家长K24奖有 允许Asgari博士在受保护的时间内成功指导了30多名实习生，从医学生到 初级教员。这项K24续展奖将允许她1)继续指导初级调查人员， 特别是NIH K23获奖者，2)在皮肤癌发生方面进行新的研究，并重新关注 表观基因组学在癌变中的变化和膳食补充剂在角质形成细胞癌风险中的作用 3)建立以皮肤癌治疗共享决策为重点的新的研究方向。 该研究计划(目标1)建立在NIAMS和NCI正在进行的由Dr. 阿斯加里。拟议的新AIMS将利用这些R01奖项的现有数据，并允许学员 使用现有数据集检查角质形成细胞癌变中的新主题的能力。此次续签将是 Asgari博士的职业成长的重要催化剂，使她能够学习和进行创新 角质形成细胞癌治疗中涉及共同决策的面向患者的研究。 本延续期间的指导计划(目标2)将允许实施结构化的 在个人层面量身定做的指导计划，以利用正式的个人发展来吸引指导对象 计划。指导结果将使用来自指导对象的匿名反馈的有效工具进行评估，以及 指导技能将通过使用指导教练来提高。Asgari博士将继续她的成功轨迹 为皮肤科住院医师、研究员和她所在机构的初级教员提供直接指导。 她未来5年的计划是利用她的努力发展以患者为导向的研究人员的职业生涯 在国家层面上。 此次K24续签将成为Asgari博士职业成长的重要催化剂，使她能够 进行创新研究并指导新的研究人员进行以患者为中心的皮肤病 研究。该计划中的指导和研究活动将为长期提供新的机会 如果没有续约期，职业轨迹是无法实现的。通过支持Asgari博士的努力 在指导方面，该奖项对她所在机构的初级调查人员来说是一项极好的投资。

Abstract The overall goals of this K24 renewal application are to continue to provide Maryam Asgari MD, MPH with protected time to serve as a mentor to junior clinical investigators, and to support new scientific aims that will build upon Dr. Asgari's established work on patient-oriented research in skin diseases. Dr. Asgari is a nationally recognized dermatoepidemiologist and Mohs surgeon and the Director of the Patient-Oriented Research in the Epidemiology of Skin Diseases (PORES) unit at Harvard Medical School. She is the principal investigator of several large patient-oriented research studies, including two NIH-funded R01s examining genetic and environmental factors impacting the development of skin cancer. The parent K24 award has allowed Dr. Asgari the protected time to successfully mentor over 30 trainees ranging from medical students to junior faculty. This K24 renewal award would allow her to 1) continue mentoring junior investigators, particularly NIH K23 awardees, 2) pursue new research in cutaneous carcinogenesis with a renewed focus on epigenomic changes in carcinogenesis and the role of dietary supplements in keratinocyte carcinoma risk, and 3) establish a new research direction focused on shared decision making in skin cancer care. The research plan (Aim 1) builds on an ongoing NIAMS- and NCI-funded portfolio of projects led by Dr. Asgari. The proposed new aims will take advantage of existing data from these R01 awards and allow mentees the ability to use existing datasets to examine novel topics in keratinocyte carcinogenesis. This renewal will be an important catalyst for Dr. Asgari’s professional growth by enabling her to learn and conduct innovative patient-facing research involving shared decision making in keratinocyte carcinoma management. The mentoring plan (Aim 2) in this continuation period will allow for the implementation of a structured mentoring program tailored at the individual level to engage mentees using a formal individual development plan. Mentoring outcomes will be assessed using a validated tool for anonymous feedback from mentees, and mentoring skills will be refined by utilizing a mentoring coach. Dr. Asgari will continue her successful trajectory of providing direct mentorship to dermatology residents, research fellows, and junior faculty at her institution. Her plan for the next 5 years is to leverage her efforts for career development of patient-oriented researchers at the national level. This K24 renewal will be an important catalyst for Dr. Asgari’s professional growth by enabling her to conduct innovative research and mentor new investigators on performing patient-oriented dermatologic research. The mentoring and research activities in this plan will open new opportunities for a long-term professional trajectory that would not be attainable without a renewal period. By supporting Dr. Asgari’s efforts in mentoring, the award is an excellent investment in the junior investigators at her institution.