Administrative, Education, and Analytic Support Core

饮酒是人类心血管疾病(CVD)的重要危险因素 与艾滋病毒感染(PLWH)。鉴于酒精使用在PLWH中很常见，心血管疾病是主要的非艾滋病 在PLWH中的疾病和死因，解决这一人群的酒精消费问题至关重要 很重要。微生物组、代谢物和酒精在HIV中减少CVD项目赠款(PPG)是一项 拥有酒精、艾滋病毒、肠道微生物组、生物标志物研究等专业知识的多学科研究小组， 营养，随机对照试验(RCT)设计。我们对此P01应用程序的总体假设 在PLWH中，益生菌可以缓解酒精相关的微生物失调和较低的微生物水平 移位、炎症和改善代谢物特征(项目1)；以及这些物质的有害程度 代谢物与心血管疾病和死亡事件的高风险相关(项目2)。为了检验这一假设，这一点 PPG将利用退伍军人老龄化队列研究，乌干达俄罗斯波士顿酒精网络 关于艾滋病毒/艾滋病的研究合作，综合代谢组和代谢组核心(IMMC)在 路易斯维尔大学酒精研究中心和范德比尔特学者在艾滋病毒和心脏，肺，血液， 和睡眠研究NIH K12初级教员培训计划，以实现这些目标：(1)确定 如果一种为酒精相关的肠道菌群失调量身定做的益生菌可以缓解这种菌群失调，微生物易位， 炎症、有害代谢物、心血管疾病和死亡风险(项目1 RCT，Lead Freiberg)； 酒精使用、心血管疾病和死亡之间通过三种代谢途径在PLWH之间的关系(项目2 (3)提供代谢组和生物标记物实验室资源(IMMC，铅 巴维)；(4)支持拟议研究的行政领导和服务(行政核心、领导 Freiberg和Barve)；以及(5)鼓励和发展未来的实习生。行政(管理)核心将是 负责PPG的日常管理和运作。管理核心目标是确保 PPG的科学和方案活动是根据《议定书》在 预算，并以最高的质量。管理核心有以下具体目标：(1)提供管理 监督PPG，包括组建一个指导委员会、方案咨询委员会和数据 安全监测委员会，并制定必要的政策和程序，以成功地组织和 完成我们的具体目标和培训计划；(2)为PPG调查人员和学员提供服务 (例如，研究进展报告、合规保证、演示文稿和出版物方面的协助)，以及 促进/传播PPG的工作；(3)提供资源(例如，数据和标本)、生物统计学 支持和指导新的调查员；(4)促进其他资助的PPG内部和之间的协同作用； (5)监督PPG组件的进度和合规性，在以下情况下实施改进机制 这是必要的，并协助调查人员应对挑战(例如，征聘)。

Alcohol consumption is an important modifiable cardiovascular disease (CVD) risk factor among people living with HIV infection (PLWH). Given that alcohol use is common among PLWH, and CVD is a leading non-AIDS disease and cause of death among PLWH, addressing alcohol consumption in this population is critically important. The Microbiome, mETabolites, and Alcohol in HIV to reduce CVD Program Project Grant (PPG) is a multidisciplinary group of investigators with expertise in alcohol, HIV, gut microbiome, biomarker research, nutrition, and randomized controlled trial (RCT) design. Our overarching hypothesis for this P01 application is that among PLWH, a probiotic can mitigate alcohol associated dysbiosis and lower levels of microbial translocation, inflammation, and improve metabolite profiles (Project 1); and that harmful levels of these metabolites are associated with higher risk of CVD and death events (Project 2). To test this hypothesis, this PPG will leverage the Veterans Aging Cohort Study, the Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS, the Integrated Metagenomic and Metabolomic Core (IMMC) at the University of Louisville Alcohol Research Center, and the Vanderbilt SCHolars in HIV and Heart, Lung, Blood, and Sleep ReSearch NIH K12 junior faculty training program to accomplish these objectives: (1) To determine if a probiotic tailored for alcohol associated gut dysbiosis mitigates this dysbiosis, microbial translocation, inflammation, harmful metabolites, CVD and mortality risk (Project 1 RCT, Lead Freiberg); (2) To assess the association between alcohol use, CVD and death via three metabolic pathways among PLWH (Project 2 Cohort, Lead So-Armah); (3) To provide metabolomic and biomarker laboratory resources (IMMC, Lead Barve); (4) Administrative leadership and services to support the proposed research (Admin Core, Leads Freiberg and Barve); and (5) Encourage and develop future trainees. The Administrative (Admin) Core will be responsible for day-to-day management and functioning of the PPG. The Admin Core goal is to ensure that the scientific and programmatic activities of the PPG are conducted per protocol in a timely fashion, within budget, and with the highest quality. The Admin Core has these specific aims: (1) To provide administrative oversight of the PPG, including assembling a steering committee, program advisory committee, and data safety monitoring board, and developing the policies and procedures necessary to successfully organize and complete our specific aims and training initiatives; (2) To provide services to PPG investigators and trainees (e.g., study progress reports, compliance assurance, assistance with presentations and publications), and to promote/disseminate the PPG'S work; (3) To provide resources (e.g., data and specimens), biostatistical support, and mentorship to new investigators ; (4) To promote synergy within and across other funded PPGs; (5) To monitor progress and compliance of the PPG's components, implement improvement mechanisms if necessary, and assist investigators with challenges (e.g., recruitment).