Administrative Core: U19

管理核心项目摘要： 这一创新的集成系统生物学应用试图描绘复杂的宿主/病原体相互作用 发生在肺泡水平，导致对严重肺炎的治疗无效。这个 管理核心将负责管理、协调和监督整个脚本范围 系统生物学中心活动。因此，管理核心将与所有内部脚本相交 调查人员以及NIAID赞助机构、其他系统生物学中心和更广泛的传染病 疾病和肺部/重症监护科学界。脚本系统生物学中心是故意 多学科，增加了交互的复杂性，并要求采用集中化的方法来促进 完成这个系统生物学中心的目标。行政核心将实现这些目标 目标三个相互关联的具体目标：目标1.提供行政和组织上的 基础设施，以促进在拟议的时限内实现脚本目标，并传播 研究项目和核心的产出。这将包括提交脚本系统生物学 将输出集中到NIAID指导的公共数据库/储存库。目标2.协调和整合两者 脚本系统生物学中心研究项目。目标3.组织当地和外部外联方案 推广系统生物学方法来治疗传染性肺炎。这包括脚本的集成 将系统生物学中心纳入当前的本地培训计划，向Gordon Research提交申请 肺炎和肺炎的系统生物学方法研究专题讨论会的会议或类似会议 向美国胸科学会提议开设关于系统生物学方法的研究生课程 肺炎。脚本系统生物学中心研究议程的主要前提是迭代方法 基于高通量组学方法的结果和结果的建模，以宿主/病原体相互作用为基础。 因此，我们预计先前的结果将推动后续的实验。整合和促进这些 不同核心和调查人员之间的后续实验将是 管理核心。行政核心的调查员还将确保项目产生的数据 核心以对更大的肺炎研究人员社区有用的格式传播。

Admin Core Project Summary: This innovative integrated systems biology application seeks to delineate the complex host/pathogen interactions occurring at the alveolar level that lead to unsuccessful response to therapy in serious pneumonia. The Administrative Core will be responsible for managing, coordinating, and supervising the entire range of SCRIPT Systems Biology Center activities. As such, the Administrative Core will intersect with all internal SCRIPT investigators as well as the NIAID sponsoring agency, other Systems Biology Centers, and the broader infectious diseases and pulmonary/critical care scientific communities. The SCRIPT Systems Biology Center is intentionally multidisciplinary, increasing the complexity of interactions and mandating a centralized approach to facilitate accomplishing the goals of this Systems Biology Center. The Administrative Core will accomplish these objectives in three interrelated specific aims: AIM 1. To provide the administrative and organizational infrastructure to facilitate accomplishment of the SCRIPT goals within proposed timelines, and to disseminate the output of the Research Projects and Cores. This will include the submission of SCRIPT Systems Biology Center output to NIAID-directed public databases/repositories. AIM 2. To coordinate and integrate the two SCRIPT Systems Biology Center Research Projects. AIM 3. To organize local and external outreach programs to promote a systems biology approach to infectious pneumonia. This includes integration of the SCRIPT Systems Biology Center into current local training programs, submission of an application to Gordon Research Conference or similar conference for a research symposium on a systems biology approach to pneumonia and a proposal to the American Thoracic Society for a post graduate course on Systems Biology Approaches to Pneumonia. The major premise of the SCRIPT Systems Biology Center research agenda is an iterative approach to host/pathogen interactions based on results of high throughput omics approaches and modeling of the results. We therefore expect that prior results will drive subsequent experiments. Integration and facilitation of these subsequent experiments between the different Cores and investigators will be the primary responsibility of the Administrative Core. Investigators in the Administrative Core will also ensure that data generated by the Projects and Cores are disseminated in formats that are useful to the larger community of pneumonia researchers.