The impact of a resistance training intervention on blood pressure control in older adults with Sarcopenia

项目摘要/摘要 为回应PA-20-272(非-OD-20-054)，现提交本申请，要求对 指导职业发展奖，K01HL148503，由国家心肺和血液资助 美国国立卫生研究院。拟议的补助金属于家长补助金的范围，其重点是 填补目前文献中有关骨质疏松症所致高血压的认识的空白 并为低肌力与血压之间的可辨别关系提供了新的证据 骨质疏松症和有效的非药物治疗方法。由于她生命中的重大事件，拉杜博士 在一个关键时刻，支持培训和研究的时间和人员有限 导致了职业发展和研究生产率方面的严重差距。本补编的目的是： 确保拉杜博士职业发展和研究培训的连续性，并促进向研究过渡 在经历了关键的人生事件后，她获得了独立。这份申请描述了拉杜博士的负面影响 对她的职业发展和研究生产力产生重大影响的人生大事。此应用程序进一步概述了Dr。 Laddu请求额外资源，以解决因以下原因而出现的生产率差距 她的关键人生事件的直接后果，并足以促进拉杜博士恢复全面研究 到补充期结束时的生产率。补充研究支持的具体请求是 双重(1)雇用更多的人员，以监督日常业务的方法交付 研究，包括协调研究方案活动和确保数据收集质量；(2)支持 需要额外的生物统计服务，以协助进行与AIM有关的数据分析和手稿准备 1和父母赠款的目标2。在该计划的支持下，拉杜博士将很好地填补差距 作为关键生活事件的负面后果而发生的生产力方面的变化，并恢复全面研究 到补充期结束时的生产率。确保研究的连续性将进一步支持拉杜博士的 开发更可靠的R级应用程序以进行评估的项目里程碑和长期目标 阻力运动对血管影响的干预效果及可能的治疗机制 不同衰弱状况的老年人的健康状况。重要的是，这一补充计划将支持Dr。 拉杜致力于职业发展和研究活动，这些活动对她的增长至关重要 研究生产力和学术能见度，并保持她在研究独立性方面的进展 老年人群的健康促进和慢性病预防方面的专家试验专家。

PROJECT SUMMARY/ABSTRACT In response to PA-20-272 (NOT-OD-20-054), this request is submitted for an administrative supplement to the mentored career development award, K01HL148503 funded through the National Heart, Lung, And Blood Institute of the NIH. The proposed supplement falls within the scope of the parent grant, which focuses on addressing current gaps in the literature regarding the understanding of high blood pressure due to sarcopenia and provides new evidence for the discernable relationship between low muscle strength and blood pressure in sarcopenia, and effective non-pharmaceutical treatment approaches. Due to her critical life event, Dr. Laddu is at a critical juncture where time constraints and limited staff to support training and research responsibilities have led to critical gaps in career development and research productivity. The objectives of the supplement are to ensure the continuity of Dr. Laddu’s career development and research training and facilitate transition to research independence, following her critical life event. This application describes the negative implications of Dr. Laddu’s critical life event on her career development and research productivity. This application further outlines Dr. Laddu’s request for additional resources that will be necessary to address gaps in productivity occurring as a direct consequence of her critical life event, and sufficient to facilitate Dr. Laddu’s return to full research productivity by the end of the supplement period. The specific request for supplemental research support is twofold (1) to hire additional personnel to oversee the methodological delivery of day-to-day operations of the study including coordinating study protocol activities and ensuring quality of data collection; (2) to support additional biostatistical services needed to assist with data analyses and manuscript preparation related to Aim 1 and Aim 2 of the parent grant. With support from this Program, Dr. Laddu will be well positioned to fulfill gaps in productivity that occurred as a negative consequence of the critical life event and resume to full research productivity by the end of the supplemental period. Ensuring continuity of research will further support Dr. Laddu’s project milestones and long-term goals of developing more definitely powered R-level applications to evaluate efficacy of the intervention and potential therapeutic mechanisms by which resistance exercise impacts vascular health in older adults with varying debilitating conditions. Importantly, this supplement program will support Dr. Laddu’s efforts to engage in career development and research activities that are critical to increasing her research productivity and scholarly visibility, and for preserving her progress towards research independence as an expert trialist in health promotion and chronic disease prevention in older adult populations.