Administrative Core

管理核心(核心A)摘要 行政核心的目标是领导和全面行政管理 确保将方案项目的愿景作为综合调查实施的方案 心脏代谢条件下雌二醇对脑和认知轨迹影响的机制 健康和疾病。行政核心有以下具体目标。1)提供资金 为所有项目和核心提供管理和一般行政支持。管理核心将承担 计划的财务责任，确保满足所有监管和报告要求，以及 管理项目的日常活动。2)提供专家生物统计和实验设计支持。 行政核心将监督PPG内使用的所有统计方法。这将包括方法 在项目内使用，也用于研究之间的比较。中心将就研究设计和结果提供建议 报道。3)提供数据管理的监督。行政核心将实施一项计划 数据监控计划，将具体说明数据的质量保证和质量控制程序。《核心》 将监督数据安全并促进项目和核心之间的数据共享。核心还将确保 收集有效和可靠的数据。4)促进项目之间的沟通和协调 核心。行政核心将组织执行委员会的每月会议，包括 研究项目和核心领导，每月计划范围内的科学会议，以及年度计划主办 研讨会。5)组织和支持咨询委员会的会议。行政核心将是 负责组织两年一次的内部会议和年度会议的相关后勤工作 和外部咨询委员会。6)提供和协调联合传播研究成果的计划。 行政核心将在两个主要领域执行联合传播成果的程序：联合 提交座谈会提案和手稿。7)对计划进行年度评估 项目。行政核心将监督所有项目和核心的年度审查。审查还将 包括衡量PPG作为协同研究计划的成功程度的指标。核心将生成 并向执行委员会和咨询委员会分发总结审查情况的报告。任何由此产生的 改进建议将在行政核心的监督下执行。

Administrative Core (Core A) Summary The goal of the Administrative Core is to provide leadership and overall administrative management to the Program to ensure implementation of the vision of the Program Project as an integrated investigation of mechanisms of estradiol effects on the brain and cognitive trajectory under conditions of cardiometabolic health and disease. The Administrative Core has the following Specific Aims. 1) To provide financial management and general administrative support to all projects and cores. The Administrative Core will assume fiscal responsibility for the Program, ensure that all regulatory and reporting requirements are met, and manage the day-to-day Program activities. 2) To provide expert biostatistical and experimental design support. The Administrative Core will oversee all statistical approaches used within the PPG. This will include methods used within projects as well as for comparison across studies. The Core will advise on study design and results reporting. 3) To provide oversight of data management. The Administrative Core will implement a Program Data Monitoring Plan that will specify procedures for quality assurance and quality control of data. The Core will oversee data security and facilitate data sharing among the projects and cores. The Core will also ensure the collection of valid and reliable data. 4) To facilitate communication and coordination between projects and cores. The Administrative Core will organize monthly meetings of the Executive Committee that includes Research Project and Core Leads, monthly Program-wide scientific meetings, and an annual Program-hosted seminar. 5) To organize and support meetings of the Advisory Boards. The Administrative Core will be responsible for the logistics associated with organizing biannual and annual meetings of the respective Internal and External Advisory Committees. 6) To provide and coordinate plans for joint dissemination of study results. The Administrative Core will implement procedures for joint dissemination of results in two primary areas: joint submissions of symposia proposals and manuscripts. 7) To conduct an annual evaluation of the Program Project. The Administrative Core will oversee an annual review of all projects and cores. The review will also include metrics to measure the success of the PPG as a synergistic research program. The Core will generate and distribute a report summarizing the review to the Executive Committee and Advisory Boards. Any resulting recommendations for improvement will be implemented with oversight from the Administrative Core.