Promoting Diverse Perspectives: Addressing Health Disparities Related to Alzheimer's and other Dementias

项目总结 阿尔茨海默氏症和其他痴呆症是美国残疾和依赖的主要原因，但不会影响 所有群体一视同仁。非洲裔美国人、美国印第安人/阿拉斯加原住民和西班牙裔/拉美裔美国人 与非拉丁裔白人和亚裔美国人相比，患痴呆症的风险更高。研究以了解和改进 健康差距应该是公共卫生的优先事项，但从历史上看，与老龄化相关的研究拨款很少 与健康差距有关。作为回应，NIA创建了健康差距研究框架(HDRF)， 它强调了环境、社会文化、行为和生物因素导致了 与年龄相关的疾病。为了推进痴呆症的差异研究，阿尔茨海默氏症协会 (Aa)将连续举办两次为期两天的会议(2021-22年)，所有 主旨演讲、全体会议、海报和其他演示文稿将映射到NIA HDFR上。目标包括：1) 加强整个科学界的合作，2)促进新研究设计和 分析方法，3)在高级职业调查人员和早期职业调查人员之间建立信息和指导桥梁， 以及4)通过NIA HDRF促进更系统的研究。每个250个面对面连接和150个远程连接 会议将在华盛顿特区举行。参加会议将是免费的，旅行和餐饮将是 适用于演讲者和会议工作组成员。机管局将支付与人事有关的费用， 会议用餐、专业联网接待、基本用品。为了实现我们的目标，五个 目标是：1)通过会议敲定会议的科学计划和所有后勤细节 制定初步计划的工作组。会议工作组由一个不同的小组组成 AA和非AA专家，由AA首席研究员卡尔·V·希尔博士领导。2)，执行 会议，题为“通过解决与阿尔茨海默氏症有关的健康差距来促进多样化的观点” 和其他需求“，包括讲座、小组讨论、海报会议、网络机会和在线 对会议的评价。3)，通过主办两次年中网络研讨会，促进这些努力的可持续性， 突出了该领域的发展。4)，通过专用海报宣传早期调查人员的职业生涯 会议、辅导/简短的演示会议和每月的社交媒体，“聚光灯”。5)，传播 通过出版会议记录和特刊来促进未来的研究 以会议和网络研讨会的研究成果为特色的相关期刊。结果将包括1) 传播阿尔茨海默氏症和其他痴呆症差异决定因素的多层次分析；2)新 痴呆症差异研究中的跨学科受精、网络和合作；3)职业生涯 加强早期职业研究人员和4)痴呆症科学的全面进步 为所有人发现新的缓解和治疗方法。

PROJECT SUMMARY Alzheimer's and other dementias are primary causes of disability and dependency in the US, but do not affect all groups equally. African Americans, American Indians/Alaska Natives, and Hispanic/Latino Americans have higher risk of dementia than non-Latino Whites and Asian Americans. Research to understand and ameliorate health disparities should be a public health priority, but historically few aging-related research grant awards relate to health disparities. In response, the NIA created the Health Disparities Research Framework (HDRF), which highlights environmental, sociocultural, behavioral, and biological factors that contribute to disparities in age-related disease. To advance disparities research in dementia specifically, the Alzheimer's Association (AA) will develop and hold two 2-day conferences, occurring in consecutive years (2021-22), for which all keynote, plenary, poster and other presentations will be mapped onto the NIA HDFR. Objectives include: 1) increase collaboration across the scientific community, 2) promote diffusion of new research designs and analytic methods, 3) create information and mentoring bridges between senior and early career investigators, and 4) promote more systematic research via the NIA HDRF. Each 250 in-person and 150 remotely-connected conference will be held in Washington, DC. Conference attendance will be free, and travel and meals will be covered for speakers and conference workgroup members. The AA will cover expenses relating to personnel, conference meals, the professional networking reception, and basic supplies. To meet our objectives, the five aims are: 1) Finalize the scientific program and all logistical details for the conference, via the Conference Workgroup that developed the preliminary program. The Conference Workgroup consists of a diverse group of AA and non-AA experts and is led by Principal Investigator, Dr. Carl V. Hill of AA. 2), Implement the conferences, entitled “Promoting Diverse Perspectives by Addressing Health Disparities Related to Alzheimer's and other Dementias”, consisting of lectures, panels, poster sessions, networking opportunities, and online evaluation of the conferences. 3), Facilitate sustainability of these efforts by hosting two mid-year webinars, highlighting developments in the field. 4), Promote the careers of early investigators via dedicated poster sessions, mentoring/short presentation sessions, and monthly social media, “spotlights.” 5), Disseminate conference findings and promote future research by publishing conference proceedings and special issues in relevant journals featuring research derived from the conferences and webinars. Results will include 1) dissemination of multi-level analyses of determinants of disparities in Alzheimer's and other dementias; 2) new cross-disciplinary fertilization, networking and collaborations in disparities research in dementia; 3) career enhancement for early career investigators and 4) overall advancement of dementia science toward the discovery of new mitigating and treatment approaches for all people.