Next Generation BiOactiVe NAnocoatings (NOVA)

NOVA旨在通过在涂层设计、最终使用和功能/安全测试之间建立有效的反馈回路，为抗菌涂层开发提供全面的方法。这包括4种涂层技术的组合优化：1)基于UV上转换器、纳米级光催化剂和疏水性碳基量子点的光激活技术；2)接触杀伤生物聚合物（多肽和多糖的链长控制超分子组装）。涂料将根据用例驱动的规格进行调整，以便能够在医院等相同环境中涂覆不同的基材。为了保证市民和环境的安全，考虑到环境风险，涂料将采用安全与可持续设计（SSbD）方法开发。NOVA将开发针对涂料优化的先进组织测试和免疫毒性测试，为监管机构提供工具，并对未来的涂料进行深入分析。为了展示实际的功效，现实生活中的模仿，将开发创新的抗菌试验。经过验证的涂料将通过利用工业合作伙伴的能力进行升级开发，用于商业开发。为了更容易采用，将在项目内设计特定的涂层应用设备。最后，项目中生成的实验数据以及联盟涂层开发人员的历史数据将用于使用机器学习方法开发预测模型，以加快未来的涂层开发方法。NOVA旨在在项目中展示的4个主要用例（纺织品、油漆、触觉电子和经常接触的具有高卫生相关性的硬表面，例如医院和公共场所的普通卫生相关性）中带来高效、环保、稳定的涂料，然后可以扩展到更广泛的应用。

NOVA aims to provide a comprehensive approach to antimicrobial coating development by creating an effective feedback loop between coating design, end use and functional/safety testing. This consists of combinatorial optimisation of 4 coating technologies: i) light activated based on: UV up-converters, nanoscale photocatalysts and hydrophobic carbon-based Quantum Dots and ii) contact killing biopolymers (chain-length controlled supramolecular assemblies of polypeptides and polysaccharides). The coatings will be adjusted in a use case driven specifications for having the capacity to coat different substrates in the same environment such as hospitals. In order to guarantee safety for citizens and environment, the coatings will be developed with a Safe and Sustainable by Design (SSbD) approach taking into account the environmental risks. NOVA will develop advanced tissue tests and immunotoxicity tests optimized for coatings to provide tools for the regulatory bodies an in depth analysis of future coatings. For demonstrating practical efficacy, real life mimicking, innovative antimicrobial tests will be developed. The validated coatings will be developed for commercial exploitation by upscaling using the capacities of the industrial partners. For easier adoption specific coating application devices will be designed within the project. Finally, the experimental data generated within the project together with the historical data of coating developers of the consortium will be used for developing predictive models using machine learning methodologies for expedited coating development methodologies in the future. NOVA aims to bring high efficiency, eco-friendly, stable coatings demonstrated within the project in 4 main use cases (textiles, paints, tactile electronics and frequently touched hard surfaces with high hygienical relevance like e.g. in hospitals and common hygienical relevance in public spaces) which can be then expanded for more widespread utilization.