Large Animal Facility for Imaging and Image-guided Therapies at MSU

摘要 精准健康是医疗保健领域的一种新兴范式，专注于早期检测和分子水平 疾病的决定因素。密歇根州立大学(MSU)在全校范围内发起了一项倡议，将 将精准健康的原则纳入其医疗系统。这一倡议的成功在很大程度上取决于 我们能够从预测性的临床前动物模型和有效的转化研究中获得相关数据。 作为精确医学基石的分子靶向诊断和治疗药物的进展， 需要在人类生物学的信息丰富的动物模型中进行可靠的测试。小型实验动物(啮齿动物) 通常在生物医学研究中使用，往往不适合研究生理学、人类 标志物、身体大小、妊娠长度、寿命和其他类似人类的特征是导致疾病的关键因素。 使用更大的动物物种进行研究，包括狗、猪和羊，可以克服其中的许多障碍。 人们普遍认为，活体成像在生物医学研究的几乎所有领域都发挥着关键作用。 和临床实践，其作用的重要性只会随着新的药物和 治疗。然而，在小动物成像系统中获得的成像数据并不总是可以直接翻译 在人类身上的研究。显然，使用临床扫描仪研究大型动物模型将产生以下数据 最接近我们对人类的期望，并将更好地为翻译研究提供信息。此外，学习的能力 作为客户临床研究的一部分，在驯化物种中自发发生的比较疾病- 拥有动物，将进一步增加翻译相关性和数据结果。 出于这些原因并促进动物模型的临床相关性，我们正在申请资金，以 在密歇根州立大学建立多物种大型动物成像设施。这个设施将配备最先进的 高端临床成像系统(PET/MRI、MMR Bioggraph、西门子)，将服务于MSU的多样化 生物医学、科学和临床社区。研究人员将使用这一设施进行大型研究 动物和客户拥有的伴侣动物，以开发成像和图像引导治疗方法 重点关注与显著死亡率有关的人类病理(例如心血管疾病、癌症和 糖尿病)。这一多学科设施还将支持正在进行的人类受试者临床试验，并作为 6所学院、12个系、7个系本科生、研究生、博士后实训场 程序。对人类和动物疾病模型进行全方位的研究。 这个新的生物医学成像设施，与密歇根州立大学的人类和兽医专业知识相结合，创造了 利用临床影像进行临床前、临床和转化性研究的绝佳机会 设备。这些能力将促进密歇根州立大学和地区调查人员之间的高层合作 和国家机构最终支持和推进一项精准医疗和 比较医学，在疾病的诊断和治疗中造福于人和动物的健康。

ABSTRACT Precision health is an emerging paradigm in healthcare that focuses on early detection and molecular determinants of disease. Michigan State University (MSU) has launched a University-wide initiative to bring the principles of precision health into its healthcare systems. The success of this initiative depends, in large part, on our ability to obtain relevant data from predictive pre-clinical animal models and effective translational research. Advances in molecularly targeted diagnostic and therapeutic agents, the cornerstones of precision medicine, require reliable testing in informative animal models of human biology. Small laboratory animals (rodents) commonly used in biomedical research are often not suitable for studying pathologies where physiology, human markers, physical size, gestation length, lifespan, and other human-like features are key contributors to disease. Use of larger animal species for research, including dogs, pigs and sheep, can overcome many of these hurdles. It is widely accepted that in vivo imaging plays a pivotal role in nearly all areas of biomedical research and clinical practice, and the importance of its role will only increase with the development of new agents and therapies. However, imaging data obtained in small animal imaging systems cannot always be directly translated to studies in humans. Clearly, studying large animal models using clinical scanners would produce data that are closest to what we expect in humans, and would better inform translational studies. Further, the ability to study comparative diseases that occur spontaneously in domesticated species, as part of clinical studies of client- owned animals, will add further to translational relevance and data outcomes. For these reasons and to advance the clinical relevance of animal models, we are requesting funds to develop a multi-species large animal imaging facility at MSU. This facility will be equipped with a state-of-the-art high-end clinical imaging system (PET/MRI, mMR Biograph, Siemens) that would serve MSU’s diverse biomedical scientific and clinical communities. Researchers will use this facility for studies of large research animals, and client-owned companion animals to develop imaging and image-guided therapy approaches with focus on human pathologies linked to significant mortality rates (e.g., cardiovascular disease, cancer, and diabetes). This multidisciplinary facility will also support ongoing clinical trials in human subjects and serve as a training ground for undergraduate, graduate and postdoctoral trainees from 6 colleges, 12 departments and 7 programs. performing research on a full spectrum of human and animal disease models. This new biomedical imaging facility, in combination with human and veterinary expertise at MSU, creates an extraordinary opportunity to perform pre-clinical, clinical and translational research using clinical imaging equipment. These capabilities will promote high-level collaborations between MSU and investigators at regional and national institutions to ultimately champion and advance a premiere program in precision health and comparative medicine, benefiting both human and animal health in the diagnosis and treatment of disease.